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Right arrow Lung - cancer

Ann Thorac Surg 2004;77:271-277
© 2004 The Society of Thoracic Surgeons

Original article: general thoracic

Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experience

Malcolm V. Brock, MDa, Min P. Kim, BAa, Craig M. Hooker, MPha, Anthony J. Alberg, PhDa, Margaret M. Jordan, RNa, Carmen M. Roig, RNa, Li Xu, BSa, Stephen C. Yang, MDa*

a The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

* Address reprint requests to Dr Yang, 624 Osler, 600 N. Wolfe St, Baltimore, MD 21287, USA
e-mail: syang{at}jhmi.edu

Presented at the Poster Session of the Thirty-ninth Annual Meeting of The Society of Thoracic Surgeons, San Diego, CA, Jan 31–Feb 2, 2003.

BACKGROUND: Recent reports indicate that age is not a contraindication to pulmonary resection for octogenarians with nonsmall cell lung cancer (NSCLC), but other data are lacking. The purpose of this study was to determine outcomes in these patients, particularly short- and long-term survival with stage I disease.

METHODS: A retrospective cohort of 68 octogenarians with NSCLC who underwent curative resection from 1980 to 2002 was followed-up for outcomes.

RESULTS: Median age was 82 years old (range, 80–87 years old) consisting of 44 males (65%), with a mean follow-up of 32 months (range, 1–178 months). Operations included: 47 lobectomies (69%), 11 wedge resections (16%), 5 segmentectomies (8%), 4 bilobectomies (6%), and 1 pneumonectomy (1%). There were 31 adenocarcinomas (46%), 18 squamous carcinomas (26%), 12 bronchioalveolar carcinomas (18%), 4 large cell carcinomas (6%), and 3 miscellaneous malignant neoplasms (4%). Median hospital stay was 7 days (range, 3–53 days). Thirty-day mortality was 8.8% (n = 6) with 83% developing cardiopulmonary complications. Overall actuarial survival at 1, 3, and 5 years was 73%, 51%, and 34%, respectively. Of 41 patients (60%) with stage I disease, 23 were T1 lesions. Five-year survival was significantly different between stages Ia and Ib patients (61% and 10%, respectively, p = 0.001). Patients in more advanced stages had a 5-year survival of 3/27 (11%). Multivariate analysis identified advanced tumor stage, lower ASA physical status, and low FEV1 as factors associated with poorer long-term survival.

CONCLUSIONS: The 5-year survival, particularly in patients with stage Ia tumors with favorable ASA and FEV1, supports the notion that health status and tumor stage outweigh chronologic age in determining surgical candidates.




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