ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Tetsuo Sakakibara
Hiroshi Takano
Hironori Izutani
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ohata, T.
Right arrow Articles by Izutani, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ohata, T.
Right arrow Articles by Izutani, H.
Related Collections
Right arrow Mechanical Circulatory Assistance

Ann Thorac Surg 2004;77:164-167
© 2004 The Society of Thoracic Surgeons

Original article: cardiovascular

Plasma brain natriuretic peptide reflects left ventricular function during percutaneous cardiopulmonary support

Toshihiro Ohata, MDa*, Tetsuo Sakakibara, MDa, Hiroshi Takano, MDa, Hironori Izutani, MDa

a Department of Cardiovascular Surgery, Osaka Police Hospital, Osaka, Japan

Accepted for publication June 25, 2003.

* Address reprint requests to Dr Ohata, Department of Cardiovascular Surgery, Kawachi General Hospital, 28 Yokomakura-Higashi, Higashi-Osaka 578-0955, Japan
e-mail: tohata{at}aol.com

BACKGROUND: Plasma levels of brain natriuretic peptide (BNP), a cardiac hormone secreted predominantly from the ventricle, are elevated in patients with myocardial infarction, hypertension, and dilated cardiomyopathy. In this study, we assessed the usefulness of measuring BNP to evaluate left ventricular function in patients with severe heart failure receiving mechanical circulatory support.

METHODS: Plasma BNP and creatine kinase (CK)-MB levels were measured serially in 8 consecutive patients with cardiogenic shock who received percutaneous cardiopulmonary support (PCPS) at Osaka Police Hospital from August 1999 to March 2000. Coronary artery bypass grafting or percutaneous transluminal coronary angioplasty was also performed in 5 patients during PCPS; in addition, 1 patient underwent insertion of a left ventricular venting catheter and implantation of a left ventricular assist system after PCPS.

RESULTS: Five patients were weaned from PCPS, and 3 died. In survivors, plasma BNP and CK-MB levels correlated positively and significantly (r = 0.968, p = 0.03). After PCPS was initiated, plasma BNP levels gradually decreased in survivors, but not in patients who died (p = 0.003).

CONCLUSIONS: These results suggest that plasma BNP levels accurately reflect myocardial damage in patients undergoing PCPS. A decrease in BNP might appear to indicate improved left ventricular function and predict successful weaning from mechanical support.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
O. Chikovani, J.-H. Hsu, R. Keller, T. R. Karl, A. Azakie, I. Adatia, P. Oishi, and J. R. Fineman
B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery.
J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1179 - 1187.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2004 by The Society of Thoracic Surgeons.