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Ann Thorac Surg 2003;76:2132-2140
© 2003 The Society of Thoracic Surgeons

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Review

Statins in coronary bypass surgery: rationale and clinical use

^a Atherosclerosis Unit, Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy,
^b Department of Cardiac Surgery, Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy
^c Department of Pharmacological Sciences, University of Milan, Milan, Italy

^* Address reprint requests to Dr Parolari, Department of Cardiac Surgery, Centro Cardiologico Monzino IRCCS, Via Parea, 4, 20138, Milan, Italy.
e-mail: aparolari{at}ccfm.it

Statin therapy prevents the first occurrence and recurrence of coronary events and reduces cardiovascular and general mortality in patients with coronary artery disease. These compounds modulate a variety of processes involved in the pathophysiology of arteriosclerosis and vascular graft disease by lipid-dependent and lipid-independent (pleiotropic) mechanisms. As a result, statins produce angiographic and clinical benefits in patients undergoing coronary bypass surgery. We review the present knowledge about the effects of statins on this pathologic condition and the evidence supporting an early treatment initiation.

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