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Ann Thorac Surg 2003;76:2102-2104
© 2003 The Society of Thoracic Surgeons

Case report

Resolved hypersensitivity myocarditis after ventricular circulatory assist

Florian Grabellus, MDa,b*, Andreas Hoffmeier, MDc, Klaus J. Schmitz, MDa, Reinhard Kandolf, MDd, Burkhard D. Bültmann, MDd, Hans-H. Scheld, MDc, Hideo A. Baba, MDa,b

a Institute of Pathology, University of Essen, Essen, Germany
b Gerhard-Domagk-Institute of Pathology, Münster, Germany
c Department of Thoracic and Cardiovascular Surgery, University of Münster, Münster, Germany
d Institute of Pathology, University of Tübingen, Tübingen, Germany

Accepted for publication April 23, 2003.

* Address reprint requests to Dr Grabellus, Institute of Pathology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
e-mail: florian.grabellus{at}medizin.uni-essen.de

Hypersensitivity myocarditis is known to be a cardiac manifestation of a delayed-type hypersensitivity response caused by drug treatment. In heart transplantation candidates the incidence is elevated. We report the case of a patient with end-stage heart failure who underwent implantation of a left ventricular assist device as a bridge to transplantation. The histologic investigation of the left ventricular specimen obtained during device implantation revealed the diagnosis of a hypersensitivity myocarditis. Ten months later this lesion showed complete reversibility within specimens of the explanted heart, maybe as a result of the termination of inotropic therapy after implantation of the left ventricular assist device.




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Reverse remodeling following insertion of left ventricular assist devices (LVAD): A review of the morphological and molecular changes
Cardiovasc Res, December 1, 2005; 68(3): 376 - 386.
[Abstract] [Full Text] [PDF]


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