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Ann Thorac Surg 2003;76:2023-2028
© 2003 The Society of Thoracic Surgeons

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Original article: cardiovascular

Differential in vitro response of the human radial artery versus left internal thoracic artery to cerivastatin: implications to bypass grafting

^a National Heart and Lung Institute, Heart Science Centre, Harefield Hospital, Harefield, Middlesex, United Kingdom

Accepted for publication June 6, 2003.

^* Address reprint requests to Dr Amrani, Consultant Surgeon, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK.
e-mail: mr.amrani{at}rbh.nthames.nhs.uk

BACKGROUND: This study investigated acute (in vitro) and long-term (in vivo) effects of statins on the vascular function of human radial artery (RA) and left internal thoracic artery (LITA).

METHODS: RA and LITA specimens were divided into vascular rings, which were incubated in the absence or presence of 10^-6 mol/L Cerivastatin for 2 or 24 hours. In terms of preoperative statin treatment, four groups included: group 1 [preop statin(-)/in vitro cerivastatin(-)]; group 2 [preop(-)/in vitro(+)]; group 3 [preop(+)/in vitro(-)]; and group 4 [preop(+)/in vitro(+)]. Endothelial function was assessed with acetylcholine (10^-9 to 10^-5 mol/L) following contraction by 3 x 10^-8 mol/L endothelin-1.

RESULTS: Although endothelium-dependent vasodilatation was higher in RA (57.7% ± 3.5%) than in LITA (46.5% ± 3.8%, p = 0.046), there was no significant evidence that it depended on the preoperative use of statins or incubation period. In vitro incubation with cerivastatin significantly increased endothelium-dependent vasodilatation by 14.2% ± 2.4% (p < 0.0001) independent of artery types (RA/LITA). There was no significant evidence that endothelium-dependent vasodilatation depended on the preoperative use of statins or incubation period.

CONCLUSIONS: In vitro incubation with cerivastatin preserved endothelial function more effectively than preoperative use of statins. This could have implications to perioperative use of statins for patients undergoing coronary surgery.

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