| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2003;76:1789-1795
© 2003 The Society of Thoracic Surgeons
a Division of Thoracic Surgery, Department of General Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
b Division of Thoracic Surgery, Department of General Surgery, Mount Sinai Medical Center and Mount Sinai School of Medicine, New York, New York, USA
* Address reprint requests to Dr Lukanich, Division of Thoracic Surgery, Department of General Surgery, Brigham and Women's Hospital, 75 Francis St, Boston, MA, USA 02115
e-mail: jlukanich{at}partners.org
Presented at the Poster Session of the Thirty-eighth Annual Meeting of The Society of Thoracic Surgeons, Fort Lauderdale, FL, Jan 28–30, 2002.
BACKGROUND: Small population studies have reported higher survival rates for women than men with non–small cell lung carcinoma (NSCLC). Because human NSCLC cells express estrogen receptors, we evaluated hormonally active and inactive women to identify biologically mediated differences.
METHODS: A total of 14,676 US women with stage I through IV primary non–small cell lung cancer (NSCLC) from the 1992 to 1997 Surveillance, Epidemiology, and End Results database were grouped into two categories based on the average menopausal age of 51 years as defined by the American College of Obstetricians and Gynecologists: ages 31 to 50 premenopausal (n = 2,230, 15%) and ages 51 to 70 postmenopausal (n = 12,446, 85%). Extreme ages were excluded. Statistics were calculated with 
2 or Mann-Whitney tests, Kaplan–Meier estimates with log-rank tests, and Cox proportional hazards models.
RESULTS: Premenopausal women more commonly presented with advanced clinical stage, less favorable histology (adenocarcinoma), and poorly differentiated tumors, and more often underwent pneumonectomies. Surgery with curative intent was performed in 31% premenopausal and 33% postmenopausal women (p = 0.03). Overall survival for premenopausal and postmenopausal women was not significantly different (median 10 and 9 months, all stages; 70 and 71 months, stages I and II). Adjusting for significant covariates (stage, histology, size, grade, extent of surgery), postmenopausal women had higher lung-cancer–related deaths (hazard ratio, 1.14; 95% confidence interval, 1.03 to 1.27).
CONCLUSIONS: Premenopausal women presented more often with advanced disease and underwent more extensive resection, yet had survival advantage after covariate adjustment. Additionally, postmenopausal women had a survival advantage compared with their male counterparts. Results suggest that estrogen exposure creates a milieu that may confer a protective effect through some yet unknown mechanisms that determine outcome of the neoplastic process and warrant further investigation.
This article has been cited by other articles:
|
|
 |
|
  T. R. Asmis, K. Ding, L. Seymour, F. A. Shepherd, N. B. Leighl, T. L. Winton, M. Whitehead, J. N. Spaans, B. C. Graham, and G. D. Goss Age and Comorbidity As Independent Prognostic Factors in the Treatment of Non-Small-Cell Lung Cancer: A Review of National Cancer Institute of Canada Clinical Trials Group Trials J. Clin. Oncol., January 1, 2008; 26(1): 54 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Y. Chang, S. J. Mentzer, Y. L. Colson, P. A. Linden, M. T. Jaklitsch, S. R. Lipsitz, and D. J. Sugarbaker Factors predicting poor survival after resection of stage IA non-small cell lung cancer. J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 850 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Wisnivesky and E. A. Halm Sex Differences in Lung Cancer Survival: Do Tumors Behave Differently in Elderly Women? J. Clin. Oncol., May 1, 2007; 25(13): 1705 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M Dougherty, W. Mazhawidza, A. R Bohn, K. A Robinson, K. A Mattingly, K. A Blankenship, M. O Huff, W. G McGregor, and C. M Klinge Gender difference in the activity but not expression of estrogen receptors {alpha} and {beta} in human lung adenocarcinoma cells. Endocr. Relat. Cancer, March 1, 2006; 13(1): 113 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Ganti, A. E. Sahmoun, A. W. Panwalkar, K. K. Tendulkar, and A. Potti Hormone Replacement Therapy Is Associated With Decreased Survival in Women With Lung Cancer J. Clin. Oncol., January 1, 2006; 24(1): 59 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Schwartz, G. M. Prysak, V. Murphy, F. Lonardo, H. Pass, J. Schwartz, and S. Brooks Nuclear Estrogen Receptor {beta} in Lung Cancer: Expression and Survival Differences by Sex Clin. Cancer Res., October 15, 2005; 11(20): 7280 - 7287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-T. Wu, Y.-L. Chang, J.-Y. Shih, and Y.-C. Lee The significance of estrogen receptor {beta} in 301 surgically treated non-small cell lung cancers J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 979 - 986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Moore, M. T. Jaklitsch, and J. M. Lukanich Reply Ann. Thorac. Surg., August 1, 2005; 80(2): 790 - 790. [Full Text] [PDF]
|
|
|
|
|
|
T. J. Birdas Menopausal Status and Non-Small Cell Lung Cancer Ann. Thorac. Surg., August 1, 2005; 80(2): 789 - 790. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Thomas, L. A. Doyle, and M. J. Edelman Lung Cancer in Women: Emerging Differences in Epidemiology, Biology, and Therapy Chest, July 1, 2005; 128(1): 370 - 381. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
