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Ann Thorac Surg 2003;76:1564-1570
© 2003 The Society of Thoracic Surgeons
a Departments of Cardiothoracic and Vascular Surgery, Jena, Germany
b Anesthesiology and Intensive Care Medicine,, Jena, Germany
c and Medical Statistics and Documentation, Friedrich-Schiller-University Hospital Jena, Jena, Germany
Accepted for publication April 18, 2003.
* Address reprint requests to Dr Albes, Department of Cardiovascular Surgery, Heart-Center-Brandenburg, Ladeburger Strasse 17, 16321, Bernau, Germany
e-mail: j.albes{at}immanuel.de
BACKGROUND: Mechanical bileaflet valves with enhanced inner diameter may offer superior hemodynamic properties in patients with a small aortic annulus. The aim of this clinical study was to compare these valves with standard bileaflet prostheses in vivo.
METHODS: Mechanical aortic valve replacement for combined stenosis and regurgitation was performed in 47 patients with standard CarboMedics prostheses (CM: 21 mm, 23 mm, 25 mm) and two types of diameter enhanced St. Jude Medical prostheses (SJM-AHPJ: 21 mm, 23 mm, 25 mm; SJM-Regent: 21 mm, 23 mm). Transvalvular mean gradients (TVG) were assessed intraoperatively by means of transesophageal echocardiography (TVGTEE) and simultaneous direct pressure monitoring of the left ventricle and the ascending aorta (TVGCATH), as well as early (3 months) and late (9 months) postoperatively by means of transthoracic echocardiography (TVGTTE). Left ventricular muscle mass was assessed preoperatively, early, and late postoperatively to evaluate remodeling capacity.
RESULTS: In all valve types and sizes, both TVG assessments exhibited consistent findings. Small-sized conventional valves of 21 mm showed a marked initial TVG. In contrast, both valve types with enhanced inner diameter exhibited significantly lower TVG comparable with those achieved with larger valves (TVGCATH CM 21 mm, 15.6 ± 3.9 mm Hg; SJM-AHPJ 21 mm, 11.9 ± 1.6 mm Hg; SJM-Regent 21 mm, 9.9 ± 1.1 mm Hg; CM 23 mm, 7.8 ± 0.8 mm Hg; SJM-AHPJ 23 mm, 7.7 ± 1.4 mm Hg; SJM-Regent 23 mm, 9.5 ± 1.8 mm Hg). During the postoperative course TVG remained constant in all valve types and sizes. Left ventricular muscle mass, however, diminished markedly in all valves without exhibiting significant differences between size matched valve types.
CONCLUSIONS: In patients with a small aortic annulus, who require a 21-mm valve, diameter-enhanced prostheses provide lower transvalvular gradients than conventional valves. However, in the intermediate clinical course, appropriate left ventricular remodeling occurred in all patients independent of the size and the type of the valve.
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Ann. Thorac. Surg. 2003 76: 1570.
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