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Ann Thorac Surg 2003;76:1246-1251
© 2003 The Society of Thoracic Surgeons

Original article: cardiovascular

Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia

Murray H. Kown, MDa, Takeshi Suzuki, MDb, Mark L. Koransky, MDa, Kalyani Penta, PhDb, Gordon Sakamoto, MDb, Christina L. Jahnckea, Andrew J. Carter, DOb, Thomas Quertermous, MDb, Robert C. Robbins, MDa*

a Department of Cardiothoracic Surgery, Stanford, California USA
b Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA

Accepted for publication April 21, 2003.

* Address reprint requests to Dr Robbins, Falk Research Building, 2nd Floor, Stanford University School of Medicine, Stanford, CA 94305-5247, USA
e-mail: robbins{at}stanford.edu

BACKGROUND: This study compared the angiogenic effects of developmental endothelial locus-1 (DEL-1), vascular endothelial growth factor (VEGF), as well as the negative control, ß-galactosidase (ß-gal), in a porcine model of cardiac ischemia.

METHODS: Twenty pigs underwent left circumflex artery occlusions. After 3 weeks, the animals received myocardial injections of adenovirus expressing ß-gal (n=6), DEL-1 (n=7), or VEGF (n=7). At 7 weeks, animals were assessed for both function and coronary flow and compared with baseline measurements.

RESULTS: Regional wall motion index and global ejection fraction showed deterioration in function in the ß-gal group and no change in the VEGF and DEL-1 groups between the treatment and harvest time points. Preload recruitable stroke work suggested functional improvement in the VEGF group (35.8 ± 8.6 vs 56.4 ± 17.8, p = 0.033). The increase in the DEL-1 group was not statistically significant (27.3 ± 9.8 vs, 40.2 ± 19.4, p = 0.067). The ß-gal group exhibited minimal change (30.7 ± 14.8 vs 35.9 ± 12.1, p = 0.96). Regional blood flow as assessed by fluorescent microspheres was improved under stress conditions in the VEGF group (1.00 ± 0.15 vs 1.15 ±0.22, p = 0.03).

CONCLUSIONS: Treatment with VEGF led to a modest improvement in regional blood flow and cardiac function in previously ischemic myocardial tissue.




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[Abstract] [Full Text] [PDF]


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