ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Paul F. Gründeman
Cornelius Borst
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Andel, C. J.
Right arrow Articles by Borst, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Andel, C. J.
Right arrow Articles by Borst, C.
Related Collections
Right arrow Coronary disease

Ann Thorac Surg 2003;76:805-809
© 2003 The Society of Thoracic Surgeons

Original article: cardiovascular

Permanent wall stretching in porcine coronary and internal mammary arteries

Carolien J. van Andel, MS, PhDa,b, Peter V. Pistecky, MSb, Paul F. Gründeman, MD, PhDa, Marc P. Buijsrogge, MD, PhDa, Cornelius Borst, MD, PhDa*

a Experimental Cardiology Laboratory, Heart Lung Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands
b Department of Design, Engineering and Production, Delft University of Technology, Delft, The Netherlands

Accepted for publication February 5, 2003.

* Address reprint requests to Dr Borst, University Medical Center Utrecht (Room G02.523), Heart Lung Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
e-mail: c.borst{at}hli.azu.nl

BACKGROUND: Anastomotic connectors may induce substantial arterial wall deformation and, hence, wall injury. We studied arterial wall damage and repair after sustained large longitudinal elongation in the porcine coronary and internal mammary arteries in vivo.

METHODS: A stretch device that elongates a part of the artery by 80% was implanted in 8 pigs. Elongated coronary arteries (n = 14) and internal mammary arteries (n = 15) were examined histologically at either 2 days (4 pigs) or 5 weeks of follow-up (4 pigs).

RESULTS: No mural thrombus was observed at the elongated site. In the coronary artery at 2 days, few and only minor histologic changes were found. At 5 weeks, in two of seven coronary segments, a thin rim of intimal hyperplasia was found, in one case with a maximum thickness of 76 µm. The internal mammary artery hardly showed any changes.

CONCLUSIONS: Permanent longitudinal elongation by 80% caused little structural changes in the porcine coronary and internal mammary artery wall. Anastomotic connectors that impose relatively large deformations can be safely evaluated in the pig.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2003 by The Society of Thoracic Surgeons.