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Right arrow Esophagus - cancer

Ann Thorac Surg 2003;76:260-265
© 2003 The Society of Thoracic Surgeons

Original article: general thoracic

Suppression of the phytohemagglutinin response to lymphocytes is an independent prognosticator in patients with squamous cell carcinoma of the esophagus

Tadahiro Nozoe, MDa*, Daisuke Korenaga, MDb, Takefumi Ohga, MDa, Motonori Futatsugi, MDa, Yoshihiko Maehara, MDa

a Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
b Department of General Surgery, Fukuoka Dental College, Fukuoka, Japan

Accepted for publication January 17, 2003.

* Address reprint requests to Dr Nozoe, Department of General Surgery, Fukuoka Dental College, 2-15-1, Tamura, Sawara Ward, Fukuoka, 814-0193, Japan
e-mail: nonta{at}college.fdcnet.ac.jp

BACKGROUND: The preoperative immunological condition of patients with malignant tumors should be considered in determining the prognosis.

METHODS: A lymphoblastic transformation test in which lymphocytes were stimulated with phytohemagglutinin (PHA) was performed for 155 patients with esophageal squamous cell carcinoma (SCC).

RESULTS: Multivariate analysis demonstrated that a lower preoperative PHA response (p = 0.028), as well as the depth of the tumor (p = 0.011), lymph node metastasis (p = 0.0003), lymphatic permeation (p = 0.002), and the incidence of postoperative complication (p = 0.016) were independent factors associated with a poor prognosis for patients with SCC of the esophagus.

CONCLUSIONS: A suppressed PHA response is an additional significant prognosticator for SCC of the esophagus.






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