HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Noriyoshi Sawabata Shin-ichi Takeda Hajime Maeda Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sawabata, N. Articles by Maeda, H. Search for Related Content PubMed PubMed Citation Articles by Sawabata, N. Articles by Maeda, H. Related Collections Lung - cancer

Ann Thorac Surg 2003;76:203-207
© 2003 The Society of Thoracic Surgeons

---

Original article: general thoracic

Immunohistochemical analysis of resectedclinical Stage I pulmonary adenocarcinomas withhigh preoperative levels of serumcarcinoembryonic antigen

^a Division of Surgery, Osaka, Japan
^b Division of Clinical Pathology, Toneyama National Hospital, Osaka, Japan
^c Division of General Thoracic Surgery, Department of Surgery (E-1), Osaka University Graduate School of Medicine, Osaka, Japan

Accepted for publication January 22, 2003.

^* Address reprint requests to Dr Sawabata, Division of Surgery, Toneyama National Hospital, 5-1-1 Toneyama, Toyonaka, Osaka, 560-8552, Japan.
e-mail: nori{at}toneyama.hosp.go.jp

BACKGROUND: Clinical stage I pulmonary adenocarcinoma (AD) patients with persistently high serum carcinoembryonic antigen (CEA) levels after surgery have a poor prognosis. Although CEA staining pattern is reported to be a prognostic indicator for patients with colorectal cancer, the relationship with lung cancer is unclear.

METHODS: One hundred eighteen patients with clinical stage I AD underwent surgery from 1993 to 1997. Of them, 19 (16%) patients with a high preoperative serum level of CEA and 19 randomly selected control patients with preoperatively normal CEA were studied. CEA staining of tumor specimens from each of the 38 patients was performed, and the staining patterns were then classified into two types: apical and diffuse.

RESULTS: Patients with normal postoperative serum CEA levels (group HN, n = 13) had a 5-year survival rate higher than those with persistently high postoperative serum CEA (group HH, n = 6). In a comparison between the two groups, apical patterns (n = 10) were only seen in group HN, and those who demonstrated an apical CEA staining pattern had a 5-year survival rate (5-YSR) of 80% as compared with 13% for those HN patients with only a diffuse pattern (p = 0.01). In the control group, 16 (84%) patients had an apical staining pattern and the other 3 patients showed no staining.

CONCLUSIONS: Patients with normalized serum CEA levels had a high chance of showing an apical staining pattern, which may be a very good prognosis predictor for patients with high preoperative levels of CEA.

This article has been cited by other articles:

				M. Inoue, T. Takakuwa, M. Minami, H. Shiono, T. Utsumi, Y. Kadota, T. Nasu, K. Aozasa, and M. Okumura Clinicopathologic factors influencing postoperative prognosis in patients with small-sized adenocarcinoma of the lung. J. Thorac. Cardiovasc. Surg., April 1, 2008; 135(4): 830 - 836. [Abstract] [Full Text] [PDF]

				W-C. Lin, Y-T. Tseng, Y-L. Chang, and Y-C. Lee Pulmonary tumour with high carcinoembryonic antigen titre caused by chronic propolis aspiration Eur. Respir. J., December 1, 2007; 30(6): 1227 - 1230. [Abstract] [Full Text] [PDF]