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Ann Thorac Surg 2003;75:S48-S57
© 2003 The Society of Thoracic Surgeons

Supplement

Infection in ventricular assist devices: prevention and treatment

William L. Holman, MDa*, Barry K. Rayburn, MDa, David C. McGiffin, MDa, Brian A. Foley, MDa, Raymond L. Benza, MDa, Robert C. Bourge, MDa, Laura J. Pinderski, MD, PhDa, James K. Kirklin, MDa

a Departments of Surgery and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

* Address reprint requests to Dr Holman, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294-0007, USA.
e-mail: wholman{at}its.uab.edu

Presented at the Heart Failure & Circulatory Support Summit, Cleveland, OH, Aug 22–25, 2002

Abstract

Infection is one of the most important challenges to the use of implanted mechanical circulatory support systems (MCSS), particularly as we enter the era of permanent device use in patients who are not candidates for cardiac transplantation. This paper describes the pathogenesis of MCSS infection, with particular attention to the role of biofilm-forming bacteria. Suggestions are presented for the prevention and treatment of infections in implanted MCSS.




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