ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hon, J. K. F.
Right arrow Articles by Yacoub, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hon, J. K. F.
Right arrow Articles by Yacoub, M. H.
Related Collections
Right arrow Mechanical Circulatory Assistance

Ann Thorac Surg 2003;75:S36-S41
© 2003 The Society of Thoracic Surgeons

Supplement

Bridge to recovery with the use of left ventricular assist device and clenbuterol

Jimmy K. F. Hon, MRCSa, Magdi H. Yacoub, FRSa*

a Department of Cardiothoracic Surgery, National Heart and Lung Institute at Royal Brompton and Harefield Hospitals, London, United Kingdom

* Address reprint requests to Dr Yacoub, Department of Cardiothoracic Surgery, Royal Brompton Hospital, Sydney St, London SW3 6NP, United Kingdom
e-mail: j.hon{at}ic.ac.uk

Presented at the Heart Failure & Circulatory Support Summit, Cleveland, OH, Aug 22–25, 2002.

Abstract

Treatment of heart failure using a left ventricular assist device (LVAD) is emerging as one of the most rapidly expanding areas. These devices are now used to treat patients with terminal heart failure not only as a bridge to transplantation but also for a bridge to recovery in certain carefully selected patients. More recently we have developed a strategy of combining LVAD support with pharmacologic therapies to produce maximal reverse remodeling followed by the induction of physiologic cardiac hypertrophy using clenbuterol, a selective ß2-adrenergic receptor agonist (the Harefield protocol). The purpose of this communication is to provide a brief review of remodeling, reverse remodeling, and the rationale for the use of clenbuterol to enhance the efficacy of the LVAD.




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
I. Ahmet, C. Morrell, E. G. Lakatta, and M. I. Talan
Therapeutic Efficacy of a Combination of a {beta}1-Adrenoreceptor (AR) Blocker and {beta}2-AR Agonist in a Rat Model of Postmyocardial Infarction Dilated Heart Failure Exceeds That of a {beta}1-AR Blocker plus Angiotensin-Converting Enzyme Inhibitor
J. Pharmacol. Exp. Ther., October 1, 2009; 331(1): 178 - 185.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
D Moore, M Anderson, and D. Larson
Effect of clenbuterol administration on the healthy murine heart
Perfusion, September 1, 2008; 23(5): 297 - 302.
[Abstract] [PDF]

Home page
 J Am Coll CardiolHome page
B. I. Jugdutt and C. Butler
Ventricular Unloading, Tissue Angiotensin II, Matrix Modulation, and Function During Left Ventricular Assist Device Support
J. Am. Coll. Cardiol., March 20, 2007; 49(11): 1175 - 1177.
[Full Text] [PDF]

Home page
 Exp PhysiolHome page
J. G. Burniston, L.-B. Tan, and D. F. Goldspink
Relative myotoxic and haemodynamic effects of the {beta}-agonists fenoterol and clenbuterol measured in conscious unrestrained rats
Exp Physiol, November 1, 2006; 91(6): 1041 - 1049.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Xydas, A. R. Kherani, J. S. Chang, S. Klotz, I. Hay, C. J. Mutrie, G. W. Moss, A. Gu, A. R. Schulman, D. Gao, et al.
beta2-Adrenergic Stimulation Attenuates Left Ventricular Remodeling, Decreases Apoptosis, and Improves Calcium Homeostasis in a Rodent Model of Ischemic Cardiomyopathy
J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 553 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
P. M. Heerdt, S. Klotz, and D. Burkhoff
Cardiomyopathic Etiology and SERCA2a Reverse Remodeling During Mechanical Support of the Failing Human Heart
Anesth. Analg., January 1, 2006; 102(1): 32 - 37.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Tsuneyoshi, W. Oriyanhan, H. Kanemitsu, R. Shiina, T. Nishina, S. Matsuoka, T. Ikeda, and M. Komeda
Does the {beta}2-Agonist Clenbuterol Help to Maintain Myocardial Potential to Recover During Mechanical Unloading?
Circulation, August 30, 2005; 112(9_suppl): I-51 - I-56.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. G. Burniston, L.-B. Tan, and D. F. Goldspink
{beta}2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle
J Appl Physiol, April 1, 2005; 98(4): 1379 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
C. Schmid, C. Etz, H. Welp, M. Rothenburger, H. Reinecke, M. Schafers, Ch. Schmidt, and H.H. Scheld
Clinical situations demanding weaning from long-term ventricular assist devices
Eur. J. Cardiothorac. Surg., October 1, 2004; 26(4): 730 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
B. Pieske
Reverse remodeling in heart failure - fact or fiction?
Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D66 - D78.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. J. Magner and D. Royston
Heart failure
Br. J. Anaesth., July 1, 2004; 93(1): 74 - 85.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
E. Braunwald
Cardiology: the past, the present, and the future
J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2031 - 2041.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2003 by The Society of Thoracic Surgeons.