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Nader Moazami
Ralph J. Damiano
Jennifer S. Lawton
Marc R. Moon
Michael K. Pasque
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Ann Thorac Surg 2003;75:1974-1976
© 2003 The Society of Thoracic Surgeons

Case report

Nesiritide (BNP) in the management of postoperative cardiac patients

Nader Moazami, MDa*, Ralph J. Damiano, MDa, Marci S. Bailey, RNa, Rachel L. Hess, RNa, Jennifer S. Lawton, MDa, Marc R. Moon, MDa, Michael K. Pasque, MDa

a Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA

Accepted for publication November 26, 2002.

* Address reprint requests to Dr Moazami, Cardiac Transplantation, Washington University School of Medicine, Barnes-Jewish Hospital, Queeny Tower, Suite 3108, One Barnes-Jewish Hospital Plaza, St. Louis, MO 63110-1013, USA
e-mail: moazamin{at}msnotes.wustl.edu

Recombinant human B-type natriuretic peptide (BNP) is a promising new agent in the management of heart failure. The pharmacologic properties of BNP make it desirable to use in a subset of patients after cardiac surgical operations. Among these therapeutic potentials is the effect on markedly reducing pulmonary vascular resistance and central venous pressure with mild systemic vasodilatation. In addition, BNP directly effects the kidneys to promote natriuresis. We believe this agent to be useful in the treatment of the postcardiac surgery patients with left ventricular dysfunction and mild to moderate renal insufficiency. This report summarizes our experience in 2 patients.




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