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Ann Thorac Surg 2003;75:1745-1751
© 2003 The Society of Thoracic Surgeons

Original article: general thoracic

Survival and prognostic factors of surgically resected T4 non-small cell lung cancer

Toshihiro Osaki, MDa*, Kenji Sugio, MDa, Takeshi Hanagiri, MDa, Mitsuhiro Takenoyama, MDa, Toshihiro Yamashita, MDa, Masakazu Sugaya, MDa, Manabu Yasuda, MDa, Kosei Yasumoto, MDa

a Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan

Accepted for publication December 31, 2002.

* Address reprint requests to Dr Osaki, Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
e-mail: t-osaki{at}med.uoeh-u.ac.jp

BACKGROUND: Category T4 nonsmall cell lung cancer (NSCLC) encompasses heterogenous subgroups. We retrospectively analyzed the survival of patients with surgically resected T4 NSCLC to evaluate the evidence for prognostic implications according to the subgroups of T4 category, nodal status, and resection completeness.

METHODS: Seventy-six patients with T4N0-2M0 NSCLC were divided into three subgroups within the T4 category: 24 patients with the tumor invading the mediastinal organs (mediastinal group), 16 with a malignant pleural effusion or dissemination (pleural group), and 36 with satellite tumor nodules within the ipsilateral primary tumor lobe (satellite group). Complete resection was possible in 47 patients (61.8%). The pathologic N statuses were N0 in 28, N1 in 13, and N2 in 35 patients.

RESULTS: The overall survival of the 76 patients was 19.1% at 5 years. The overall 5-year survivals according to the three subgroups of the T4 category were as follows: mediastinal group, 18.2%; pleural group, 0%; and satellite group, 26.7% (mediastinal/satellite versus pleural, p = 0.037). Factors significantly influencing the overall 5-year survival were the pathologic N status (N2 versus N0-1, p = 0.022) and the completeness of resection (complete versus incomplete, p = 0.0001). A multivariate survival analysis demonstrated that the pathologic N status and the completeness of resection were significant independent predictors of a poorer prognosis even after adjusting for the subgroup of the T4 category.

CONCLUSIONS: Resectable T4N0-1 NSCLC that is not due to pleural disease deserves consideration of aggressive surgical resection with expected 5-year survival of about 20%.




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