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Jonathan R.S Day
Mark Ali
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Ann Thorac Surg 2003;75:1648-1650
© 2003 The Society of Thoracic Surgeons


Case report

Castleman’s disease associated with myasthenia gravis

Jonathan R.S Day, MRCSa,*, Duncan Bew, MBBSa, Mark Ali, FRCSa, Roberto Dina, FRC(Path)b, Peter L.C Smith, FRCSa

a Departments of Cardiothoracic Surgery, London, United Kingdom
b Pathology, Hammersmith Hospital, London, United Kingdom

Accepted for publication November 1, 2002.

* Address reprint requests to Dr Day, Department of Cardiothoracic Surgery, Hammersmith Hospital, Du Cane Rd, London W12 0HS, UK (Email: j.day{at}ic.ac.uk).

Castleman’s disease presents as a peculiar type of lymph node hyperplasia. Traditionally, the disease has been classified on clinical grounds (solitary or multicentric) and by histologic appearance (hyaline vascular pattern, plasma cell predominance, or mixed lesions). It is now increasingly clear that there are different etiologies for each of these different subtypes. Reported associations include POEMS syndrome (polyneuropathy, organomegally, endocrinopathy, monoclonal gammopathy, and skin changes), paraneoplastic pemphigus, Hodgkin’s disease, and follicular dendritic cell sarcoma. We present a case of Castleman’s disease associated with myasthenia gravis, the third reported case in the literature. We discuss Castleman’s disease and review the literature.







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