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Ann Thorac Surg 2003;75:S729-S734
© 2003 The Society of Thoracic Surgeons

II: Surgical myocardial protection

Current strategies for optimizing the use of cardiopulmonary bypass in neonates and infants

Irving Shen, MDa, Carmen Giacomuzzi, CCPa, Ross M. Ungerleider, MDa*

a Doernbecher Children’s Hospital, Oregon Health & Science University, Portland, Oregon, USA

* Address reprint requests to Dr Ungerleider, Doernbecher Children’s Hospital, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code L353, Portland, OR 97201, USA.
e-mail: ungerlei{at}ohsu.edu

Presented at the 3rd International Symposium on Myocardial Protection From Surgical Ischemic-Reperfusion Injury, Asheville, NC, June 2–6, 2002.

Abstract

The use of cardiopulmonary bypass is still necessary for the repair of many congenital cardiac defects. However, exposure to cardiopulmonary bypass can still lead to major morbidity and sometimes mortality, especially in neonates and infants, despite a perfect surgical repair. Various research-based strategies have been used to minimize some of the complications related to cardiopulmonary bypass, including the systemic inflammatory response, hemodilution, and transfusion requirement. This overview provides some of the strategies that we use in our practice in applying cardiopulmonary bypass in the repair of congenital cardiac defects in neonates and infants.




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