ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
David J. Chambers
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chambers, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chambers, D. J.
Related Collections
Right arrow Myocardial protection

Ann Thorac Surg 2003;75:S661-S666
© 2003 The Society of Thoracic Surgeons

I: Pathophysiology of ischemic-reperfusion injury

Mechanisms and alternative methods of achieving cardiac arrest

David J. Chambers, PhDa*

a Cardiac Surgical Research/Cardiothoracic Surgery, The Rayne Institute, Guy’s and St Thomas’ NHS Hospital Trust, St Thomas’ Campus, London SE1 7EH, United Kingdom

* Address reprint requests to Dr Chambers, Cardiac Surgical Research, Cardiothoracic Surgery, The Rayne Institute, Guy’s and St Thomas’ NHS Hospital Trust, St Thomas’ Campus, London SE1 7EH, UK.
e-mail: david.chambers{at}kcl.ac.uk

Presented at the 3rd International Symposium on Myocardial Protection From Surgical Ischemic-Reperfusion Injury, Asheville, NC, June 2–6, 2002.

Abstract

Elective cardiac arrest during surgery can be achieved by inducing depolarization, polarization, or influencing calcium mechanisms. Depolarized arrest, induced by elevating the extracellular potassium concentration, is currently the most commonly used technique. However, injury associated with ionic imbalance involving sodium and calcium overload, together with maintained metabolic processes aimed at correcting these imbalances, have lead to alternatives being sought. "Polarized" arrest, induced by sodium-channel blockers or by agents that activate potassium channels, has been shown to exert equal or superior protection. Similarly, agents that induce calcium desensitization may also prove to enhance protection. These alternative techniques, however, require extensive characterization before introduction into routine clinical use can be recommended.




This article has been cited by other articles:


Home page
 ICVTSHome page
Y. Maruyama and D. J. Chambers
Myocardial protection: efficacy of a novel magnesium-based cardioplegia (RS-C) compared to St Thomas' Hospital cardioplegic solution
Interactive CardioVascular and Thoracic Surgery, October 1, 2008; 7(5): 745 - 749.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
O. Jakobsen, S. Muller, E. Aarsaether, T. Steensrud, and D. G. Sorlie
Adenosine instead of supranormal potassium in cardioplegic solution improves cardioprotection
Eur. J. Cardiothorac. Surg., September 1, 2007; 32(3): 493 - 500.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. A. Carney, J. Chen, C. G. Burns, K. M. Xiong, R. E. Peterson, and W. Heideman
Aryl Hydrocarbon Receptor Activation Produces Heart-Specific Transcriptional and Toxic Responses in Developing Zebrafish
Mol. Pharmacol., August 1, 2006; 70(2): 549 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Steensrud, D. Nordhaug, K. V. Husnes, E. Aghajani, and D. G. Sorlie
Replacing potassium with nicorandil in cold St. Thomas' Hospital cardioplegia improves preservation of energetics and function in pig hearts
Ann. Thorac. Surg., April 1, 2004; 77(4): 1391 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
D. J. Chambers
Nicorandil cardioplegia or procaine cardioplegia?
Eur. J. Cardiothorac. Surg., October 1, 2003; 24(4): 670 - 670.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2003 by The Society of Thoracic Surgeons.