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Alan P. Kypson
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Ann Thorac Surg 2003;75:579-581
© 2003 The Society of Thoracic Surgeons

Case report

Paroxysmal cold hemoglobinuria and cardiopulmonary bypass

Alan P. Kypson, MDa, John J. Warner, MDb, Marilyn J. Telen, MDc, Carmelo A. Milano, MDa*

a Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina, USA
b Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
c Division of Hematology, Duke University Medical Center, Durham, North Carolina, USA

Accepted for publication August 22, 2002.

* Address reprint requests to Dr Milano, Department of Surgery, Duke University Medical Center, Box 3043, Durham, NC 27710, USA.
e-mail: milan002{at}mc.duke.edu

Paroxysmal cold hemoglobinuria, a cold-reactive autoimmune disease associated with the Donath-Landsteiner antibody, has not been described in patients undergoing cardiac surgery. We report a case of mitral valve replacement in a woman with a positive Donath-Landsteiner antibody and a history of recurrent hemolysis and hemoglobinuria secondary to cold exposure. Successful perioperative management is described, as is a discussion of paroxysmal cold hemoglobinuria.




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Y. Naito, M. Nakajima, H. Inoue, and K. Tsuchiya
Successful CABG in a patient with paroxysmal nocturnal hemoglobinuria
Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 468 - 470.
[Abstract] [Full Text] [PDF]


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