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Ann Thorac Surg 2003;75:534-537
© 2003 The Society of Thoracic Surgeons

Original article: cardiovascular

A tumor necrosis factor gene polymorphism influences the inflammatory response after cardiac operation

Stefan Schroeder, MDa*, Nicole Börger, MDa, Hermann Wrigge, MDa, Armin Welz, MDb, Christian Putensen, MDa, Andreas Hoeft, MD, PhDa, Frank Stüber, MDa

a Departments of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
b Department ofCardiac Surgery, University of Bonn, Bonn, Germany

Accepted for publication August 29, 2002.

* Address reprint requests to Dr Schroeder, Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund-Freud-Straße 25, D-53105 Bonn, Germany
e-mail: schroed{at}ukb.uni-bonn.de

BACKGROUND: The genetic background may influence cytokine release evoked by cardiac operation. Thus we determined the allele frequency and genotype distribution of a bi-allelic tumor necrosis factor (TNF) gene polymorphism and TNF-{alpha} concentrations in patients undergoing cardiac operations with and without cardiopulmonary bypass (CPB).

METHODS: The TNF NcoI gene polymorphism was identified by polymerase chain reaction followed by restriction analysis of the polymerase chain reaction product. Reading the size of the resulting DNA bands from the agarose gel defined the genotype as homozygous or heterozygous for the two alleles TNFB1 and TNFB2. Blood samples to determine TNF-{alpha} plasma levels were drawn from the patients before induction of general anesthesia after termination of CPB or after finishing coronary revascularization on the beating heart in non-CPB patients and 12 hours postoperatively.

RESULTS: The genotype distribution and allele frequencies in 47 patients undergoing cardiac operation with CPB were comparable with those found in 36 patients undergoing cardiac operation without CPB. The TNF-{alpha} plasma levels over time were comparable in patients with and without CPB. However, patients homozygous for the TNF-B2 allele had significantly higher TNF-{alpha} plasma levels after termination of the CPB (40.2 ± 3.5 pg/mL; mean ± standard error of the mean; n = 28) compared with non-CPB patients (29.8 ± 2.5 pg/mL; mean ± standard error of the mean; n = 15) (p < 0.05).

CONCLUSIONS: Patients homozygous for the TNF-B2 allele showed significantly higher TNF-{alpha} plasma levels after termination of CPB compared with non-CPB patients. Therefore preoperative TNF genotyping may be useful as patients with genetically determined increased proinflammatory cytokine expression with multiple comorbidities may in particular benefit from avoiding the use of CPB.




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