ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Thomas K. Waddell
Thomas R.J. Todd
Shaf H. Keshavjee
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by de Perrot, M.
Right arrow Articles by Keshavjee, S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Perrot, M.
Right arrow Articles by Keshavjee, S. H.
Related Collections
Right arrow Lung - transplantation

Ann Thorac Surg 2003;75:367-371
© 2003 The Society of Thoracic Surgeons

Original article: general thoracic

Bronchogenic carcinoma after solid organ transplantation

Marc de Perrot, MDa, Dennis A. Wigle, MDa, Andrew F. Pierre, MDa, Ming S. Tsao, MDa, Thomas K. Waddell, MDa, Thomas R.J. Todd, MDa, Shaf H. Keshavjee, MDa*

a Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada

Accepted for publication August 29, 2002.

* Address reprint requests to Dr Keshavjee, Division of Thoracic Surgery, Toronto General Hospital, E10-224, 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada.
e-mail: shaf.keshavjee{at}uhn.on.ca

BACKGROUND: This study assesses the risk of bronchogenic carcinoma after solid organ transplantation. Although the overall incidence of malignancy is increased after solid organ transplantation, the risk of bronchogenic carcinoma in the transplant population has not been systematically studied.

METHODS: Among a cohort of 3,374 patients transplanted in our institution between 1985 and 2000 (1,735 kidney recipients, 930 liver, 313 heart, and 396 lung recipients), 9 patients (0.3%) had a bronchogenic carcinoma develop. Lung carcinoma occurred in 3 kidney recipients, 3 liver recipients, 2 heart recipients, and 1 lung recipient.

RESULTS: Time to diagnosis after the transplant procedure ranged from 9 to 126 months (mean, 63 months). Aside from the lung transplant candidate, all recipients had a smoking history. Seven patients underwent thoracotomy and 6 had a complete resection. Tumors were classified as stage IA (n = 1), IB (n = 2), IIB (n = 2), IIIA (n = 2), IIIB (n = 1), and IV (n = 1). Genotyping demonstrated that the carcinoma arising in the lung transplant recipient originated from the donor and may have been transmitted at the time of transplantation. Two patients were alive without recurrence 21 and 42 months after the operation.

CONCLUSIONS: The risk of bronchogenic carcinoma is low and occurs mainly in recipients with a smoking history. However, bronchogenic carcinoma can also be transmitted from donor lungs at the time of transplantation. Hence careful examination of chest roentgenograms, and computed tomographic chest scan if available, as well as meticulous assessment of the lung, and biopsy of any suspicious lesions, are important to limit the risk of lung cancer transmission, especially with the liberalization of donor criteria.




This article has been cited by other articles:


Home page
 RadioGraphicsHome page
M. S. Krishnam, R. D. Suh, A. Tomasian, J. G. Goldin, C. Lai, K. Brown, P. Batra, and D. R. Aberle
Postoperative Complications of Lung Transplantation: Radiologic Findings along a Time Continuum
RadioGraphics, July 1, 2007; 27(4): 957 - 974.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P N Chhajed, L Bubendorf, H Hirsch, A Boehler, W Weder, and M Tamm
Mesothelioma after lung transplantation.
Thorax, October 1, 2006; 61(10): 916 - 917.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
P. Bagan, J. Assouad, P. Berna, R. Souilamas, F. Le Pimpec Barthes, and M. Riquet
Immediate and Long-Term Survival After Surgery for Lung Cancer in Heart Transplant Recipients
Ann. Thorac. Surg., February 1, 2005; 79(2): 438 - 442.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
Z. Ahmed, M. B. Marshall, J. C. Kucharczuk, L. R. Kaiser, and J. B. Shrager
Lung Cancer in Transplant Recipients: A Single-Institution Experience
Arch Surg, August 1, 2004; 139(8): 902 - 906.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2003 by The Society of Thoracic Surgeons.