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Ann Thorac Surg 2003;75:356-363
© 2003 The Society of Thoracic Surgeons

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Original article: general thoracic

Survival in primary lung cancer potentially cured by operation: influence of tumor stage and clinical characteristics

^a Department of Thoracic and Cardiovascular Surgery, Uppsala University Hospital, Uppsala, Sweden
^b Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
^c Department of Oncology, Uppsala University Hospital, Uppsala, Sweden

Accepted for publication August 24, 2002.

* Address reprint requests to Dr Myrdal, Uppsala University Hospital, Department of Thoracic and Cardiovascular Surgery, SE-751 85 Uppsala, Sweden.
e-mail: gunnar.myrdal{at}thorax.uas.lul.se

BACKGROUND: Surgical resection is currently standard treatment in early stage lung cancer. The aim of the present study was to identify stage-related factors and patient characteristics influencing survival after complete resection.

METHODS: We identified 395 patients with non-small cell lung cancer who had undergone potentially radical operation during 1987 to 1999 at one thoracic surgery institution in central Sweden. Factors independently related to survival were identified in a multivariate analysis. Survival was analyzed in low-, medium-, and high-risk groups based on a risk score calculated from relative hazards for identified risk factors.

RESULTS: Overall 5-year survival among the 395 patients was 51%. The strongest factor predicting prognosis was positive lymph nodes at operation. Higher age, earlier period for operation, impaired lung function, current smoking, and major operative complication were all related to poorer prognosis. Patients with tumor stage Ia had a 5-year survival of 69%, compared to 73% in patients in the low-risk group.

CONCLUSIONS: Tumor stage is the best prognostic indicator after radical operation. Inclusion of other tumor- and patient-related variables did not add prognostic information of clinical relevance beyond that provided by tumor stage alone.

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