| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2003;75:231-236
© 2003 The Society of Thoracic Surgeons
a Department of Thoracic and Cardiovascular Surgery, Homburg/Saar, Germany
b Department of Nuclear Medicine, Homburg/Saar, Germany
c Department of Internal Medicine V (Pneumology), Saarland University Medical School, Homburg/Saar, Germany
* Address reprint requests to Dr Graeter, Department of Thoracic and Cardiovascular Surgery, Saarland University Medical School, 66421 Homburg, Germany.
e-mail: dl5ban{at}t-online.de
Presented at the Thirty-eighth Annual Meeting of The Society of Thoracic Surgeons, Fort Lauderdale, FL, Jan 28–30, 2002.
BACKGROUND: In patients with bronchogenic carcinoma, mediastinal lymph node staging is essential for determining treatment options. In this retrospective analysis we compared the results of positron emission tomography (PET) using F-18 fluorodeoxyglucose with those of mediastinoscopy in nodal staging for suspected bronchogenic carcinoma.
METHODS: From March 1997 to June 2001, 102 patients (86 male,16 female, age 62 ± 9 years) underwent both PET and mediastinoscopy for radiologically suspected mediastinal lymph node disease in bronchogenic carcinoma. Total body emission scans were acquired 90 to 150 minutes after injection of 230 MBq of F-18 fluorodeoxyglucose. Mediastinoscopic evaluation of lymph node stations was performed according to the method of Mountain and Dresler (1R,1L, 2L, 2R, 4L, 4R,7). Patients were eligible if surgical staging was performed within 6 weeks after the PET scan.
RESULTS: Of the 102 patients, benign lesions were diagnosed in 15. In 87 patients malignant disease was proven by histology, and bronchogenic carcinoma was found in 82. Of 469 nodal stations analyzed, malignancy was documented by histology in 84. In PET analysis 79 true-positive and 304 true-negative samples were found. Five lymph node stations were false negative, and 81 samples were false positive. False-positive findings in PET frequently were seen in inflammatory lung disease. The sensitivity of PET was 94.1%, specificity was 79% with a diagnostic accuracy of 81.6%. The positive predictive value of PET was 49.3%, and the negative predictive value was 98.4%.
CONCLUSIONS: In patients with positive PET scan results histologic verification appears necessary for exact lymph node staging. In view of the negative predictive value mediastinoscopy can be omitted in patients with bronchogenic carcinoma whose PET scan results were negative.
This article has been cited by other articles:
|
|
 |
|
  H. Nomori, T. Mori, K. Ikeda, K. Kawanaka, S. Shiraishi, K. Katahira, and Y. Yamashita Diffusion-weighted magnetic resonance imaging can be used in place of positron emission tomography for N staging of non-small cell lung cancer with fewer false-positive results. J. Thorac. Cardiovasc. Surg., April 1, 2008; 135(4): 816 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Melek, M. Z. Gunluoglu, A. Demir, H. Akin, A. Olcmen, and S. I. Dincer Role of positron emission tomography in mediastinal lymphatic staging of non-small cell lung cancer Eur. J. Cardiothorac. Surg., February 1, 2008; 33(2): 294 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ebihara, H. Nomori, K. Watanabe, T. Ohtsuka, T. Naruke, K. Uno, I. Kuwahira, and K. Eguchi Characteristics of Advantages of Positron Emission Tomography over Computed Tomography for N-staging in Lung Cancer Patients Jpn. J. Clin. Oncol., November 1, 2006; 36(11): 694 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Bryant, R. J. Cerfolio, K. M. Klemm, and B. Ojha Maximum Standard Uptake Value of Mediastinal Lymph Nodes on Integrated FDG-PET-CT Predicts Pathology in Patients with Non-Small Cell Lung Cancer Ann. Thorac. Surg., August 1, 2006; 82(2): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Meyers, F. Haddad, B. A. Siegel, J. B. Zoole, R. J. Battafarano, N. Veeramachaneni, J. D. Cooper, and G. A. Patterson Cost-effectiveness of routine mediastinoscopy in computed tomography- and positron emission tomography-screened patients with stage I lung cancer J. Thorac. Cardiovasc. Surg., April 1, 2006; 131(4): 822 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hellwig, T. P. Graeter, D. Ukena, T. Georg, C.-M. Kirsch, and H.-J. Schafers Value of F-18-fluorodeoxyglucose positron emission tomography after induction therapy of locally advanced bronchogenic carcinoma J. Thorac. Cardiovasc. Surg., December 1, 2004; 128(6): 892 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Schrevens, N. Lorent, C. Dooms, and J. Vansteenkiste The Role of PET Scan in Diagnosis, Staging, and Management of Non-Small Cell Lung Cancer Oncologist, November 1, 2004; 9(6): 633 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Okubo, T. Kato, A. Hara, N. Yoshimi, K. Takeda, and F. Iwao Imprint Cytology for Detecting Metastasis of Lung Cancer in Mediastinal Lymph Nodes Ann. Thorac. Surg., October 1, 2004; 78(4): 1190 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Cerfolio, B. Ojha, A. S. Bryant, V. Raghuveer, J. M. Mountz, and A. A. Bartolucci The accuracy of integrated PET-CT compared with dedicated pet alone for the staging of patients with nonsmall cell lung cancer Ann. Thorac. Surg., September 1, 2004; 78(3): 1017 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D.L. Sihoe, T. W. Lee, A. T. Ahuja, and A. P.C. Yim Should cervical ultrasonography be a routine staging investigation for lung cancer patients with impalpable cervical lymph nodes? Eur. J. Cardiothorac. Surg., April 1, 2004; 25(4): 486 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nomori, K. Watanabe, T. Ohtsuka, T. Naruke, K. Suemasu, and K. Uno The size of metastatic foci and lymph nodes yielding false-negative and false-positive lymph node staging with positron emission tomography in patients with lung cancer J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 1087 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Kelly, T. Tran, A. Holmstrom, J. Murar, and R. J. Segurola Jr Accuracy and Cost-Effectiveness of [18F]-2-Fluoro-Deoxy-D-Glucose-Positron Emission Tomography Scan in Potentially Resectable Non-small Cell Lung Cancer Chest, April 1, 2004; 125(4): 1413 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Port, M. S. Kent, R. J. Korst, R. Keresztes, M. A. Levin, and N. K. Altorki Positron emission tomography scanning poorly predicts response to preoperative chemotherapy in non-small cell lung cancer Ann. Thorac. Surg., January 1, 2004; 77(1): 254 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Gould, W. G. Kuschner, C. E. Rydzak, C. C. Maclean, A. N. Demas, H. Shigemitsu, J. K. Chan, and D. K. Owens Test Performance of Positron Emission Tomography and Computed Tomography for Mediastinal Staging in Patients with Non-Small-Cell Lung Cancer: A Meta-Analysis Ann Intern Med, December 2, 2003; 139(11): 879 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Reed, D. H. Harpole, K. E. Posther, S. L. Woolson, R. J. Downey, B. F. Meyers, R. T. Heelan, H. A. MacApinlac, S.-H. Jung, G. A. Silvestri, et al. Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancer J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1943 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Cerfolio, B. Ojha, A. S. Bryant, C. S. Bass, A. A. Bartalucci, and J. M. Mountz The role of FDG-PET scan in staging patients with nonsmall cell carcinoma Ann. Thorac. Surg., September 1, 2003; 76(3): 861 - 866. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
