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Ann Thorac Surg 2002;74:2179-2181
© 2002 The Society of Thoracic Surgeons

Case report

Systemic-to-pulmonary artery shunt thrombosis in a neonate with factor V Leiden mutation

Janet M. Simsic, MDa*, Walter E. Uber, PharmDb, John Lazarchick, MDc, Scott M. Bradley, MDd

a Pediatric Cardiology. Medical University of South Carolina, Charleston, South Carolina, USA
b Pharmacy Services, Medical University of South Carolina, Charleston, South Carolina, USA
c Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
d Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA

Accepted for publication July 1, 2002.

* Address reprint requests to Dr Simsic, Division of Pediatric Cardiology, Medical University of South Carolina, 165 Ashley Ave, P.O. Box 250915, Charleston, SC 29425; USA.
e-mail: simsicjm{at}musc.edu

We present the case of a newborn male with D-transposition of the great arteries, ventricular septal defect, and subpulmonary stenosis who experienced two episodes of systemic-to-pulmonary artery shunt thrombosis. Hematologic evaluation revealed heterozygous factor V Leiden mutation. This report emphasizes the importance of evaluation for inherited coagulation disorders in pediatric patients with unexpected thrombotic complications.




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