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Ann Thorac Surg 2002;74:2177-2179
© 2002 The Society of Thoracic Surgeons

Case report

Anticoagulation with bivalirudin during cardiopulmonary bypass in cardiac surgery

Julio C. Vasquez, MDa, Anna Vichiendilokkul, PharmDb, Syed Mahmood, MDc, Frank A. Baciewicz, Jr, MDa*

a Department of Cardiothoracic Surgery, Harper University Hospital, Wayne State University, Detroit, Michigan, USA
b Department of Pharmacy, Harper University Hospital, Wayne State University, Detroit, Michigan, USA
c Department of Cardiology, Harper University Hospital, Wayne State University, Detroit, Michigan, USA

Accepted for publication July 10, 2002.

* Address reprint requests to Dr Baciewicz, Department of Cardiothoracic Surgery, Harper University Hospital, 3990 John R, Suite 2101, Detroit, MI 48201, USA.
e-mail: fbaciewi{at}dmc.org

Heparin is the standard agent used for systemic anticoagulation during cardiopulmonary bypass in cardiac operations. Alternatives are needed when patients with heparin-induced thrombocytopenia type II are encountered. We present a patient with a clinical picture of heparin-induced thrombocytopenia type II who was effectively anticoagulated with bivalirudin, a direct thrombin inhibitor, during cardiopulmonary bypass for a cardiac operation.




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