HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Sidney Chocron Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Falcoz, P.-E. Articles by Etievent, J.-P. Search for Related Content PubMed PubMed Citation Articles by Falcoz, P.-E. Articles by Etievent, J.-P. Related Collections Myocardial protection

Ann Thorac Surg 2002;74:2156-2160
© 2002 The Society of Thoracic Surgeons

---

Original article: cardiovascular

Warm and tepid cardioplegia

Do they provide equal myocardial protection?

^a Department of Thoracic and Cardiovascular Surgery, Besançon, France
^b Department of Pharmacology, Hôpital Jean-Minjoz, Besançon, France
^c Department of Biostatistics and Epidemiology, Faculté de Médecine et de Pharmacie, Besançon, France
^d Department of Public Health, Hôpital Saint-Jacques, Besançon, France

Accepted for publication June 30, 2002.

* Address reprint requests to Dr Falcoz, Department of Thoracic and Cardiovascular Surgery, Hôpital Jean-Minjoz, Boulevard Fleming, 25000 Besançon, France
e-mail: pierre-emmanuel.falcoz{at}wanadoo.fr

BACKGROUND: Cardiac troponin I (CTnI) has been shown to be a marker of myocardial injury. The aim of this prospective, randomized study was to compare intermittent antegrade warm cardioplegia with tepid blood cardioplegia in patients undergoing first elective coronary artery bypass graft, using CTnI release as the criterion for evaluating the adequacy of myocardial protection.

METHODS: Seventy patients were randomly assigned to one of two cardioplegia groups. CTnI concentrations were measured in serial venous blood samples drawn immediately before cardiopulmonary bypass and after aortic unclamping at 6, 9, 12, and 24 hours. Analysis of covariance with repeated measures was performed to test the effect of the type of cardioplegia and time on CTnI concentration.

RESULTS: The total amount of CTnI released (8.23 ± 20.5 µg in the warm group and 3.19 ± 2.4 µg in the tepid group) was not statistically different (p = 0.23). The CTnI concentration did not differ for any sample in either of the two groups when adjusted on ejection fraction and the number of preoperative myocardial infarctions (p = 0.06). No patient in the tepid group versus 4 patients in the warm group showed CTnI evidence of perioperative myocardial infarction (p = 0.12).

CONCLUSIONS: Our study showed no preference for warm or tepid cardioplegia in terms of myocardial protection, either for clinical or biological data.

This article has been cited by other articles:

				Y. Durandy and S. Hulin Intermittent warm blood cardioplegia in the surgical treatment of congenital heart disease: Clinical experience with 1400 cases J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 241 - 246. [Abstract] [Full Text] [PDF]

				K. Alwan, P.-E. Falcoz, J. Alwan, W. Mouawad, G. Oujaimi, S. Chocron, and J.-P. Etievent Beating versus arrested heart coronary revascularization: evaluation by cardiac troponin I release Ann. Thorac. Surg., June 1, 2004; 77(6): 2051 - 2055. [Abstract] [Full Text] [PDF]