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Ann Thorac Surg 2002;74:2121-2125
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

Excess coronary artery bypass graft mortality among women with hypothyroidism

Dlear Zindrou, MDa, Kenneth M. Taylor, MDa, Jens Peder Bagger, MDa*

a Cardiothoracic Directorate, Hammersmith Hospital, and Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, London, England, UK

Accepted for publication July 22, 2002.

* Address reprint requests to Dr Bagger, Cardiothoracic Directorate, Hammersmith Hospital, Du Cane Rd, London W12 0NN, England United Kingdom.
e-mail: p.bagger{at}ic.ac.uk

BACKGROUND: The impact of thyroid disease on patients undergoing coronary artery bypass grafting has been reported in only small series of selected patients.

METHODS: We investigated 30-day mortality of patients on thyroxine replacement therapy undergoing isolated coronary artery bypass grafting from 1993 to 2000 and identified variables of importance for outcome.

RESULTS: A total of 3,631 patients (606 women) had isolated coronary artery bypass grafting of whom 58 patients (30 women) were treated for hypothyroidism. The mortality rate was higher among women with thyroxine replacement (16.7%, 95% confidence interval [CI] 5.6 to 34.7) than those without thyroxine replacement (5.9%, 95% CI 4.1 to 8.2; p = 0.02) and no difference between men with (3.6%, 95% CI 0.1 to 17.8) and without (2.6%, 95% CI 2.0 to 3.2) thyroxine treatment (p = 0.8). Intake of diuretics (p < 0.001) was directly associated with mortality whereas intake of aspirin (p = 0.01), levothyroxine dose (p = 0.03), and serum thyroxine level (p = 0.01) were inversely associated with mortality among women on thyroxine replacement.

CONCLUSIONS: Women on thyroxine replacement therapy undergoing coronary artery bypass grafting had an increased mortality rate. We speculate that insufficient thyroid hormone replacement could partly play a role in this outcome.




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