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Ann Thorac Surg 2002;74:1576-1580
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

Neuron loss after coronary artery bypass detected by SPECT estimation of benzodiazepine receptors

Lars S. Rasmussen, MD, PhDa*, Bjørn Sperling, MDb, Hanne H. Abildstrøm, MD, PhDa, Jakob T. Moller, MD, DMSca

a Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
b Department of Neurology, Neuro Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

Accepted for publication June 26, 2002.

* Address reprint requests to Dr Rasmussen, Department of Anaesthesia, Centre of Head and Orthopaedics, 4132, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
e-mail: lsr{at}rh.dk

BACKGROUND: Cerebral dysfunction is common after cardiac surgery and probably related to embolic phenomena, but the etiological mechanisms have not been elucidated. The aim of this study was to assess whether a possible neuron loss could be detected by single photon emission computer tomography (SPECT) estimation of benzodiazepine receptor density. In addition, we correlated the findings with neuropsychological test results.

METHODS: We included 15 elderly patients undergoing coronary artery bypass surgery. Neuropsychological testing was performed before surgery and postoperatively at discharge from hospital and after 3 months using a neuropsychological test battery. SPECT was performed before surgery and after 3 months using the iomazenil bolus/infusion technique, and the benzodiazepine receptor density was calculated for the frontal, parietal, temporal, and occipital cortex.

RESULTS: Cognitive dysfunction was found in 46.7% at discharge from hospital and in 6.7% after 3 months. A significant decrease in the estimated density of neurons was found in the frontal cortex, but no significant correlation was found between cognitive dysfunction and SPECT findings.

CONCLUSIONS: Neuron loss was detectable in the frontal cortex, but the decrease did not correlate with neuropsychological test results.




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L. Gao, R. Taha, D. Gauvin, L. B. Othmen, Y. Wang, and G. Blaise
Postoperative Cognitive Dysfunction After Cardiac Surgery
Chest, November 1, 2005; 128(5): 3664 - 3670.
[Abstract] [Full Text] [PDF]


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