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Ann Thorac Surg 2002;74:S1383-S1389
© 2002 The Society of Thoracic Surgeons

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Supplement: Cardiothoracic Techniques and Technologies

Coronary perfusion methods during off-pump coronary artery bypass: results of a randomized clinical trial

^a Pensacola Heart Institute, Sacred Heart and Baptist Hospitals, Pensacola, Florida, USA

* Address reprint requests to Dr Vassiliades, Cardiothoracic Surgical Associates of Northwest Florida, 5151 North Ninth Avenue, Suite 200, Pensacola, FL 32504 USA
e-mail: vassiliades{at}pol.net

Presented at the Eighth Annual Cardiothoracic Techniques and Technologies Meeting 2002, Miami Beach, FL, Jan 23–26, 2002.

BACKGROUND: Several techniques are being used to perform off-pump coronary artery bypass (OPCAB) grafting. This three-armed clinical trial was performed to determine whether one OPCAB method of coronary perfusion was superior over the others with respect to myocardial protection and performance.

METHODS: Over the course of 11 months, 151 consecutive unselected patients underwent elective first-time OPCAB grafting by sternotomy performed by a single surgeon. Patients were prospectively randomized to receive one of three OPCAB coronary perfusion treatments: (1) no coronary perfusion (NCP), ie, OPCAB using no coronary perfusion during the distal anastomosis or graft perfusion after the distal anastomosis until all the proximal anastomoses were completed; (2) passive coronary perfusion (PCP), providing distal coronary perfusion during the anastomosis and immediate graft perfusion after the distal anastomosis by means of a passive cannula from the aorta; or (3) active coronary perfusion (ACP), providing assisted distal coronary perfusion and graft perfusion by means of an in-line pump (perfusion-assisted direct coronary artery bypass. Hemodynamic and biochemical data were recorded to disc continuously throughout the operation and postoperatively.

RESULTS: With no statistically significant differences in the three treatment groups with respect to patient age, left ventricular systolic or diastolic function, and extent and distribution of coronary disease or grafts performed, cardiac performance postoperatively was superior in the active coronary perfusion group compared to the groups receiving either passive coronary perfusion or no coronary perfusion (p < 0.001). In addition, troponin I levels were lower in the coronary perfusion groups (PCP and ACP) (p = 0.023).

CONCLUSIONS: Providing active coronary perfusion during the anastomosis and after each distal anastomosis by using an in-line pump resulted in superior myocardial protection and performance during OPCAB surgery when compared to either no coronary perfusion or passive coronary perfusion.

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