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Ann Thorac Surg 2002;74:1271-1275
© 2002 The Society of Thoracic Surgeons

Review

Immunology and failure of valved allografts in children

Robert E. Shaddy, MDa*, John A. Hawkins, MDb

a Department of Pediatrics University of Utah School of Medicine and Primary Children’s Medical Center, Salt Lake City, Utah, USA
b Department of Surgery, University of Utah School of Medicine and Primary Children’s Medical Center, Salt Lake City, Utah, USA

* Address reprint requests to Dr Shaddy, Division of Pediatric Cardiology, Primary Children’s Medical Center, 100 North Medical Dr, Suite 1500, Salt Lake City, UT84113, USA.
e-mail: pcrshadd{at}ihc.com

Valved allografts are frequently used in the repair of congenital heart defects in children. Although the longevity of these grafts is generally very good, there continue to be ongoing problems with allograft stenosis, allograft valve insufficiency, and subsequent allograft failure, particularly in younger children. This review presents data on the immunologic and nonimmunologic risk factors implicated in valved allograft failure, in addition to ongoing investigation into the improvement of allograft function.




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