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Ann Thorac Surg 2002;74:910-912
© 2002 The Society of Thoracic Surgeons

Case report

Recombinant factor VIIa after aortic valve replacement in a patient with osteogenesis imperfecta

Marc Kastrup, MDa, Christian von Heymann, MD*a, Holger Hotz, MDb, Wolfgang F. Konertz, MD, PhDb, Sabine Ziemer, MDc, Wolfgang J. Kox, MD, PhDa, Claudia Spies, MDa

a Department of Anesthesiology and Intensive Care Medicine, University Hospital Charité, Campus Mitte, Berlin, Germany
b Department of Cardiovascular Surgery, University Hospital Charité, Campus Mitte, Berlin, Germany
c Institute of Laboratory Medicine and Pathological Biochemistry, University Hospital Charité, Campus Mitte, Berlin, Germany

Accepted for publication April 1, 2002.

* Address reprint requests to Dr von Heymann, Department of Anesthesiology and Intensive Care Medicine, University Hospital Charité Campus Mitte, Schumannstr 20-21, D-10117 Berlin, Germany
e-mail: christian.von.heymann{at}rz.hu-berlin.de

A 26-year-old man with osteogenesis imperfecta and severe aortic regurgitation was scheduled for aortic valve replacement. As previously described by other authors the operation was difficult owing to the friability and weakness of the tissues. Mean blood losses of 153 mL per hour during the first 7 postoperative hours were observed. Despite normal coagulation indicators the bleeding did not stop and recombinant factor VIIa was applied at 40 µg/kg. Bleeding was successfully stopped after this single application.




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