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Ann Thorac Surg 2002;74:488-492
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

Transmyocardial coil implants: a novel approach to transmyocardial revascularization

David Meerkin, MBBSc,d, Michel Pellerin, MDb, H. Thomas Aretz, MDe, Patrice Paiement, MSa, Stuart L. Houser, MDe, Raoul Bonan, MD*a

a Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
b Department of Surgery, Montreal Heart Institute, Montreal Quebec, Canada
c Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
d Department of Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel
e Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

Accepted for publication April 25, 2002.

* Address reprint requests to Dr Bonan, Montreal Heart Institute, 5000 Belanger St, Montreal, Quebec HIT 1C8, Canada
e-mail: raoul.bonan{at}mmic.net

Background. Transmyocardial laser revascularization (TMLR) has potential benefit for patients with end-stage coronary artery disease and intractable angina not amenable to conventional revascularization techniques. Neovascularization has been proposed to occur around the laser channels. Our aim was to determine the feasibility of a novel nonlaser myocardial revascularization technique and its effect on angiogenesis in a nonischemic porcine model.

Methods. In the first phase, six transmyocardial stainless steel coil implants (TMI) were deployed to the lateral wall of the left ventricle in each of 6 pigs. The animals were sacrificed at 8 and 12 weeks, with a single animal dying prematurely at 4 weeks, and the myocardium was assessed for new vessel growth. In the second phase, 8 implants were deployed in each of 12 pigs with regular fluoroscopic follow-up until sacrifice at 2 weeks to assess implant stability.

Results. The deployment procedure was safe and feasible with no complications evident. A significant increase in new vessels at implant sites with 5.43 ± 3.67, 4.97 ± 2.44, and 3.57 ± 2.29 seen per high power field at 12, 8, and 4 weeks, respectively, compared to 1.00 ± 1.06 (p < 0.0001) in control myocardium. There was no evidence of implant migration in Phase 2.

Conclusions. TMIs can feasibly be deployed in the nonischemic pig model with a high success rate. The presence of angiogenesis at the implant site and the maintenance of this reaction for 3 months implies that TMI may offer an alternative to TMLR while providing a platform for delivery of angiogenic factors.






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