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Ann Thorac Surg 2002;73:2005-2011
© 2002 The Society of Thoracic Surgeons


Review

Determining the extent of cognitive change after coronary surgery: a review of statistical procedures

Alexander Collie, PhD*a,c, David G. Darby, PhDb,c, Marina G. Falleti, BBSc (Hons)a,d, Brendan S. Silbert, MDe, Paul Maruff, PhDa,d

a Neuropsychology Laboratory, Mental Health Research Institute of Victoria, Parkville, Australia
b Behavioural Neurology Laboratory, Mental Health Research Institute of Victoria, Parkville, Australia
c Center for Neuroscience, The University of Melbourne, Parkville, Australia
d School of Psychological Science, La Trobe University, Bundoora, Australia
e Centre for Anesthesia and Cognitive Function, St. Vincent’s Hospital, Melbourne, Victoria, Australia

* Address reprint requests to Dr Collie, Neuropsychology Laboratory, Mental Health Research Institute of Victoria, Locked Bag 11, Parkville, Victoria 3052, Australia
e-mail: alex{at}neuro.mhri.edu.au

Currently, cognitive decline after coronary surgery is said to be significant if the individual’s postoperative test score is at least 1 standard deviation (SD) worse than their preoperative score. This "1-SD" technique fails to account for factors that may confound interpretation of serially acquired cognitive test scores, including regression to the mean, measurement error caused by poor test-retest reliability, and practice effects. We review the many alternative and potentially superior statistical techniques that have been described in the neuropsychologic and psychiatric literature for differentiating "true" changes in cognitive test score from changes caused by these factors.




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