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Ann Thorac Surg 2002;73:1995-2004
© 2002 The Society of Thoracic Surgeons
a Division of General Thoracic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
b Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
* Address reprint requests to Dr Grillo, Massachusetts General Hospital, Blake 1570, 55 Fruit Street, Boston, MA 02114 USA
e-mail: pguerriero{at}partners.org
This review discusses the need for tracheal replacement, distinct from resection with primary anastomosis, the requirements for replacement, and the many efforts over the past century to accomplish this goal experimentally and clinically. Approaches have included use of foreign materials, nonviable tissue, autogenous tissue, tissue engineering, and transplantation. Biological problems in each category are noted.
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