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Ann Thorac Surg 2002;73:1919-1926
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects

Jay G. Shake, MDa, Peter J. Gruber, MD, PhDa, William A. Baumgartner, MDa, Guylaine Senechal, MSb, Jennifer Meyers, BSb, J. Mark Redmond, MDa, Mark F. Pittenger, PhDb, Bradley J. Martin, PhD*b

a The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
b Osiris Therapeutics, Inc, Baltimore, Maryland, USA

* Address reprint requests to Dr Martin, Osiris Therapeutics, Inc, 2001 Aliceanna St, Baltimore, MD 21231 USA
e-mail: bmartin{at}osiristx.com

Presented at the Thirty-seventh Annual Meeting of The Society of Thoracic Surgeons, New Orleans, LA, Jan 29–31, 2001.

Background. A novel therapeutic option for the treatment of acute myocardial infarction involves the use of mesenchymal stem cells (MSCs). The purpose of this study was to investigate whether implantation of autologous MSCs results in sustained engraftment, myogenic differentiation, and improved cardiac function in a swine myocardial infarct model.

Methods. MSCs were isolated and expanded from bone marrow aspirates of 14 domestic swine. A 60-minute left anterior descending artery occlusion was used to produce anterior wall infarction. Piezoelectric crystals were placed within the ischemic region for measurement of regional wall thickness and contractile function. Two weeks later animals autologous, Di-I–labeled MSCs (6 x 107) were implanted into the infarct by direct injection. Hemodynamic and functional measurements were obtained weekly until the time of sacrifice. Immunohistochemistry was used to assess MSC engraftment and myogenic differentiation.

Results. Microscopic analysis showed robust engraftment of MSCs in all treated animals. Expression of muscle-specific proteins was seen as early as 2 weeks and could be identified in all animals at sacrifice. The degree of contractile dysfunction was significantly attenuated at 4 weeks in animals implanted with MSCs (5.4% ± 2.2% versus -3.37% ± 2.7% in control). In addition, the extent of wall thinning after myocardial infarction was markedly reduced in treated animals.

Conclusions. Mesenchymal stem cells are capable of engraftment in host myocardium, demonstrate expression of muscle specific proteins, and may attenuate contractile dysfunction and pathologic thinning in this model of left ventricular wall infarction. MSC cardiomyoplasty may have significant clinical potential in attenuating the pathology associated with myocardial infarction.




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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [PDF]

Home page
 Physiol. Rev.Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. A. Laflamme, J. Gold, C. Xu, M. Hassanipour, E. Rosler, S. Police, V. Muskheli, and C. E. Murry
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
PNAS, August 9, 2005; 102(32): 11474 - 11479.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
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Effects of bone marrow derived mesenchymal stem cells transplantation in acutely infarcting myocardium
Eur J Heart Fail, August 1, 2005; 7(5): 730 - 738.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Dow, B. Z. Simkhovich, L. Kedes, and R. A. Kloner
Washout of transplanted cells from the heart: A potential new hurdle for cell transplantation therapy
Cardiovasc Res, August 1, 2005; 67(2): 301 - 307.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. Sordi, M. L. Malosio, F. Marchesi, A. Mercalli, R. Melzi, T. Giordano, N. Belmonte, G. Ferrari, B. E. Leone, F. Bertuzzi, et al.
Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets
Blood, July 15, 2005; 106(2): 419 - 427.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. C. Wollert and H. Drexler
Mesenchymal Stem Cells for Myocardial Infarction: Promises and Pitfalls
Circulation, July 12, 2005; 112(2): 151 - 153.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
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Ann. Thorac. Surg., July 1, 2005; 80(1): 229 - 237.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
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J. Thorac. Cardiovasc. Surg., July 1, 2005; 130(1): 173 - 179.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
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Bone marrow stem cell transplantation for cardiac repair
Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2557 - H2567.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. Matsumoto, T. Omura, M. Yoshiyama, T. Hayashi, S. Inamoto, K.-R. Koh, K. Ohta, Y. Izumi, Y. Nakamura, K. Akioka, et al.
Vascular Endothelial Growth Factor-Expressing Mesenchymal Stem Cell Transplantation for the Treatment of Acute Myocardial Infarction
Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1168 - 1173.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
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Stimulation of Paracrine Pathways With Growth Factors Enhances Embryonic Stem Cell Engraftment and Host-Specific Differentiation in the Heart After Ischemic Myocardial Injury
Circulation, May 17, 2005; 111(19): 2486 - 2493.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Aggarwal and M. F. Pittenger
Human mesenchymal stem cells modulate allogeneic immune cell responses
Blood, February 15, 2005; 105(4): 1815 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. C. Wollert and H. Drexler
Clinical Applications of Stem Cells for the Heart
Circ. Res., February 4, 2005; 96(2): 151 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
B. Dawn and R. Bolli
Bone marrow cells for cardiac regeneration: the quest for the protagonist continues
Cardiovasc Res, February 1, 2005; 65(2): 293 - 295.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. Davani, F. Deschaseaux, D. Chalmers, P. Tiberghien, and J.-P. Kantelip
Can stem cells mend a broken heart?
Cardiovasc Res, February 1, 2005; 65(2): 305 - 316.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. V. Silva, S. Litovsky, J. A.R. Assad, A. L.S. Sousa, B. J. Martin, D. Vela, S. C. Coulter, J. Lin, J. Ober, W. K. Vaughn, et al.
Mesenchymal Stem Cells Differentiate into an Endothelial Phenotype, Enhance Vascular Density, and Improve Heart Function in a Canine Chronic Ischemia Model
Circulation, January 18, 2005; 111(2): 150 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
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Morphological, electrophysiological and coupling characteristics of bone marrow-derived mononuclear cells--an in vitro-model
Eur. J. Cardiothorac. Surg., January 1, 2005; 27(1): 104 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Kucia, B. Dawn, G. Hunt, Y. Guo, M. Wysoczynski, M. Majka, J. Ratajczak, F. Rezzoug, S. T. Ildstad, R. Bolli, et al.
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Circ. Res., December 10, 2004; 95(12): 1191 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
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Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2670 - H2676.
[Abstract] [Full Text] [PDF]

Home page
 JRSMHome page
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Adult bone-marrow stem cells and their potential in medicine
J R Soc Med, October 1, 2004; 97(10): 465 - 471.
[Full Text] [PDF]

Home page
 JCBHome page
A. J. Engler, M. A. Griffin, S. Sen, C. G. Bonnemann, H. L. Sweeney, and D. E. Discher
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments
J. Cell Biol., September 13, 2004; 166(6): 877 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
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Bone marrow stromal cells improve cardiac performance in healed infarcted rat hearts
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H464 - H470.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Cellular cardiomyoplasty: clinical application
Ann. Thorac. Surg., March 1, 2004; 77(3): 1121 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. F. Heubach, E. M. Graf, J. Leutheuser, M. Bock, B. Balana, I. Zahanich, T. Christ, S. Boxberger, E. Wettwer, and U. Ravens
Electrophysiological properties of human mesenchymal stem cells
J. Physiol., February 1, 2004; 554(3): 659 - 672.
[Abstract] [Full Text] [PDF]

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 J. Thorac. Cardiovasc. Surg.Home page
S. Fazel, R. D. Weisel, and R.-K. Li
Reply to the Editor
J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 2114 - 2115.
[Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
W. Deng, T. J. Bivalacqua, N. N. Chattergoon, A. L. Hyman, J. R. Jeter Jr., and P. J. Kadowitz
Adenoviral gene transfer of eNOS: high-level expression in ex vivo expanded marrow stromal cells
Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1322 - C1329.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
A. Bel, E. Messas, O. Agbulut, P. Richard, J. L. Samuel, P. Bruneval, A. A. Hagege, and P. Menasche
Transplantation of Autologous Fresh Bone Marrow Into Infarcted Myocardium: A Word of Caution
Circulation, September 9, 2003; 108(90101): II-247 - 252.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
S. Davani, A. Marandin, N. Mersin, B. Royer, B. Kantelip, P. Herve, J.-P. Etievent, and J.-P. Kantelip
Mesenchymal Progenitor Cells Differentiate into an Endothelial Phenotype, Enhance Vascular Density, and Improve Heart Function in a Rat Cellular Cardiomyoplasty Model
Circulation, September 9, 2003; 108(90101): II-253 - 258.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
J. S. Forrester, M. J. Price, and R. R. Makkar
Stem Cell Repair of Infarcted Myocardium: An Overview for Clinicians
Circulation, September 2, 2003; 108(9): 1139 - 1145.
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 CirculationHome page
J. M. Hill, A. J. Dick, V. K. Raman, R. B. Thompson, Z.-X. Yu, K. A. Hinds, B. S.S. Pessanha, M. A. Guttman, T. R. Varney, B. J. Martin, et al.
Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells
Circulation, August 26, 2003; 108(8): 1009 - 1014.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
E. N. Olson and M. D. Schneider
Sizing up the heart: development redux in disease
Genes & Dev., August 15, 2003; 17(16): 1937 - 1956.
[Full Text] [PDF]

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 Ann. Thorac. Surg.Home page
P. Menasche
Cell transplantation in myocardium
Ann. Thorac. Surg., June 1, 2003; 75(90060): S20 - 28.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
D. L. Kraitchman, A. W. Heldman, E. Atalar, L. C. Amado, B. J. Martin, M. F. Pittenger, J. M. Hare, and J. W.M. Bulte
In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction
Circulation, May 13, 2003; 107(18): 2290 - 2293.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
O. Agbulut, M.-L. Menot, Z. Li, F. Marotte, D. Paulin, A. A. Hagege, C. Chomienne, J.-L. Samuel, and P. Menasche
Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy
Cardiovasc Res, May 1, 2003; 58(2): 451 - 459.
[Abstract] [Full Text] [PDF]


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