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Ann Thorac Surg 2002;73:1822-1829
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

Patient prosthesis mismatch is rare after aortic valve replacement: valve size may be irrelevant

Naoji Hanayama, MDa, George T. Christakis, MD*a, Hari R. Mallidi, MDa, Campbell D. Joyner, MDa, Stephen E. Fremes, MDa, Christopher D. Morgan, MDa, Peter R.R. Mitoffa, Bernard S. Goldman, MDa

a Division of Cardiovascular Surgery of Sunnybrook and Women’s College Health Sciences Centre, Toronto, Ontario, Canada

* Address reprint requests to Dr Christakis, Sunnybrook and Women’s College Health Sciences Centre, H406-2075 Bayview Ave, Toronto, Ontario M4N 3M5, Canada
e-mail: george.christakis{at}swchsc.on.ca

Presented at the Thirty-seventh Annual Meeting of The Society of Thoracic Surgeons, New Orleans, LA, Jan 29–31, 2001.

Background. Although small valve size and patient-prosthesis mismatch are both considered to decrease long-term survival, little direct evidence exists to support this hypothesis.

Methods. To assess the prevalence of patient-prosthesis mismatch and the influence of small valve size on survival, we prospectively studied 1,129 consecutive patients undergoing aortic valve replacement between 1990 and 2000. Mean and peak gradients and indexed effective orifice area were measured by transthoracic echocardiography postoperatively (3 months to 10 years). Abnormal postoperative gradients were defined as those patients with mean or peak gradient above the 90th percentile (mean gradient >= 21 or peak gradient >= 38 mm Hg). Patient-prosthesis mismatch was defined as those patients with indexed effective orifice area below the 10th percentile (< 0.60 cm2/m2).

Results. A multivariable analysis identified internal diameter of the implanted valve as the only independent predictor of abnormal gradients postoperatively. However, there was no significant difference in actuarial survival between normal and abnormal gradient groups (7 years: 91.2% ± 1.5% versus 95.0% ± 2.2%; p = 0.48). Freedom from New York Heart Association class III or IV (7 years: 74.5% ± 3.1% versus 74.6% ± 6.2%; p = 0.66) and left ventricular mass index were not different between normal and abnormal gradient groups. Patients with and without patient-prosthesis mismatch were similar with respect to postoperative left ventricular mass index, 7-year survival (95.1% ± 1.3% versus 94.7% ± 3.0%; p = 0.54), and 7-year freedom from New York Heart Association class III or IV (79.3% ± 6.6% versus 74.5% ± 2.5%; p = 0.40). In patients with patient-prosthesis mismatch and abnormal gradients, the majority had prosthesis dysfunction owing to degeneration.

Conclusions. Severe patient-prosthesis mismatch is rare after aortic valve replacement. Patient-prosthesis mismatch, abnormal gradient, and the size of valve implanted do not influence left ventricular mass index or intermediate-term survival.




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[Abstract] [Full Text] [PDF]

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 CirculationHome page
C. Blais, J. G. Dumesnil, R. Baillot, S. Simard, D. Doyle, and P. Pibarot
Impact of Valve Prosthesis-Patient Mismatch on Short-Term Mortality After Aortic Valve Replacement
Circulation, August 26, 2003; 108(8): 983 - 988.
[Abstract] [Full Text] [PDF]

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 Eur Heart JHome page
O. Lund, K. Emmertsen, I. Dorup, F. T. Jensen, and C. Flo
Regression of left ventricular hypertrophy during 10 years after valve replacement for aortic stenosis is related to the preoperative risk profile
Eur. Heart J., August 1, 2003; 24(15): 1437 - 1446.
[Abstract] [Full Text] [PDF]

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 J. Thorac. Cardiovasc. Surg.Home page
A. M. Gillinov, E. H. Blackstone, and L. L. Rodriguez
Prosthesis-patient size: measurement and clinical implications
J. Thorac. Cardiovasc. Surg., August 1, 2003; 126(2): 313 - 316.
[Full Text] [PDF]

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 Card Surg AdultHome page
N. D. Desai and G. T. Christakis
Stented Mechanical/Bioprosthetic Aortic Valve Replacement
, January 1, 2003; 2(2003): 825 - 856.
[Full Text]

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 Ann. Thorac. Surg.Home page
S. Bevilacqua, J. Gianetti, A. Ripoli, U. Paradossi, A. Giuseppe Cerillo, M. Glauber, M. L. Sacha Matteucci, M. Senni, A. Gamba, E. Quaini, et al.
Aortic valve disease with severe ventricular dysfunction: stentless valve for better recovery
Ann. Thorac. Surg., December 1, 2002; 74(6): 2016 - 2021.
[Abstract] [Full Text] [PDF]


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