ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Tsung-Po Tsai
Jung-Min Yu
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsai, T.-P.
Right arrow Articles by Chen, F.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsai, T.-P.
Right arrow Articles by Chen, F.-L.
Related Collections
Right arrow Congenital - acyanotic

Ann Thorac Surg 2002;73:1765-1768
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

Change of serum growth factors in infants with isolated ventricular defect undergoing surgical repair

Tsung-Po Tsai, MD*a, Jung-Min Yu, MDa, Yi-Liang Wu, MDa, Chih-Yang Huang, PhDb, Fong-Lin Chen, MDc

a Division of Cardiovascular Surgery, Chung Shan Medical University and Hospital, Taichung, Taiwan, China
b Division of Biochemistry, Chung Shan Medical University and Hospital, Taichung, Taiwan, China
c Division of Pediatric Cardiology, Chung Shan Medical University and Hospital, Taichung, Taiwan, China

Accepted for publication February 4, 2002.

* Address reprint requests to Dr Tsai, No. 110, Sec l, Chien-Kuo N. Road, Taichung, Taiwan, China
e-mail: tsai{at}csh.org.tw

Background. Despite increasing clinical use and recent evidence that insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and human growth hormone (hGH) target the heart, the clinical manifestations following the change in the serum growth factors in infants with isolated ventricular septal defect (VSD) undergoing surgical repair have not been clearly defined.

Methods. Twenty normal infants (group I) and 44 consecutive infants with echocardiography established isolated VSD (aged from 3 months to 1 year; body weight from 6.0 ± 1.8 kg to 8.2 ± 1.6 kg) were investigated. Among 44 infants with VSD, 20 with shunt fraction, Qp/Qs <=1.5 were free of symptoms of congestive heart failure (group II); 24 with shunt fraction, Qp/Qs >=2.0 were in congestive heart failure (group IIIa); and 20 of these 24 infants had undergone VSD repair 6 months before their second study (group IIIb). Serum IGF-1, IGFBP-3, and hGH factors were determined by enzyme-linked immunosorbent assay using a monoclonal antibody.

Results. The serum levels of IGF-1, IGFBP-3, and hGH factors were 111.9 ± 2.3 ng/mL, 22.0 ± 2.3 ng/mL, and 3.6 ± 0.7 µIU/mL for group I; 63.8 ± 8.2 ng/mL, 17.1 ± 1.6 ng/mL, and 4.1 ± 1.2 µIU/mL for group II; 24.0 ± 2.6 ng/mL, 9.4 ± 0.7 ng/mL, and 14.7 ± 3.5 µIU/mL for group IIIa; 79.4 ± 12 ng/mL, 20.3 ± 1.3 ng/mL, and 4.3 ± 0.7 µIU/mL for group IIIb. In comparison to group I, the decrease in serum levels of IGF-1 and IGFBP-3 in groups II and IIIa were statistically significant (in group II 43% and 32%, p < 0.05; in group IIIa 79% and 37%, p < 0.01). Also the increase in serum level of hGH concentration in group IIIa was significant (increased threefold, p < 0.01). Interestingly, the change in serum levels of IGF-1, IGFBP-3 (decrease), and hGH (increase), returned to the normal range of serum levels after VSD repair in group IIIb. All congestive heart failure symptoms subsided in group IIIb during follow-up.

Conclusions. Improvement in serum levels of IGF-1, IGFBP-3, and hGH were identified in infants with VSD after surgical repair.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2002 by The Society of Thoracic Surgeons.