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Ann Thorac Surg 2002;73:1747-1751
© 2002 The Society of Thoracic Surgeons

Original article: general thoracic

Survival analysis of rats implanted with porous titanium tracheal prosthesis

Philippe Schultz, MDa, Dominique Vautier, PhDb, Johanna Chluba, PhDb, Luc Marcellin, MDc, Christian Debry, MD, PhD*a

a Department of Otolaryngology-Head and Neck Surgery, Hautepierre Hospital, Strasbourg, France
b Department of Anatomo-Pathology, Hautepierre Hospital, Strasbourg, France
c INSERM 424, Centre de Recherche Odontologique, Strasbourg, France

Accepted for publication February 26, 2002.

* Address reprint requests to Prof Debry, Hôpital de Hautepierre, Avenue Molière, 67098 Strasbourg Cedex, France
e-mail: christian.debry{at}chru-strasbourg.fr

Background. Surgical treatment of a malignancy in the trachea may lead to a long resection that has to be reconstructed with an artificial prosthesis. However, most of the available prostheses encounter inflammatory rejection and mechanical constraint problems. To improve tracheal rehabilitation a porous titanium prosthesis was developed. The aim of this study was to test the biocompatibility of this novel material.

Results. Fibroblast colonization of titanium pores and a ciliary cylindrical epithelial layer developed on the endoluminal side of the prosthesis and the inflammatory reaction was minimal.

Conclusions. The results of this short-term study validate, from surgical and histologic standpoints, the usefulness of a porous titanium tracheal prosthesis.




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 Arch Otolaryngol Head Neck SurgHome page
L. M. Janssen, G. J. V. M. van Osch, J. P. Li, N. Kops, K. de Groot, J. W. Von den Hoff, L. Feenstra, and J. A. U. Hardillo
Tracheal Reconstruction: Mucosal Survival on Porous Titanium
Arch Otolaryngol Head Neck Surg, May 1, 2009; 135(5): 472 - 478.
[Abstract] [Full Text] [PDF]


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