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Ann Thorac Surg 2002;73:1697-1703
© 2002 The Society of Thoracic Surgeons

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Original article: general thoracic

High-grade esophageal dysplasia: long-term survival and quality of life after esophagectomy

^a Division of General Thoracic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
^b Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

* Address reprint requests to Dr Nichols, Division of General Thoracic Surgery, Mayo Clinic and Mayo Foundation, 200 First St, SW, Rochester, MN 55905 USA
e-mail: nichols.francis{at}mayo.edu

Presented at the Thirty-seventh Annual Meeting of the Society of Thoracic Surgeons, New Orleans, LA, Jan 29–31, 2001.

Background. Esophagectomy for high-grade dysplasia in Barrett’s esophagus has been advocated. Although long-term survival data exist, little is known about functional outcome and quality of life in this particular subset of patients.

Methods. The records of all patients who underwent esophageal resection for high-grade dysplasia from June 1991 through July 1997 were reviewed. Long-term functional outcome and quality of life were assessed using a two-part written survey.

Results. There were 54 patients (48 men, 6 women). Median age was 64 years (range, 36 to 83 years). Ivor Lewis esophagogastrectomy was performed in 34 patients (63%), transhiatal esophagectomy in 10 (18%), extended esophagectomy in 8 (15%), and other in 2 (4%). Invasive carcinoma was found in 19 patients (35%). Five patients (9%) were stage 0, 7 (13%) stage I, 3 (6%) stage IIA, 1 (2%) stage IIB, and 3 patients (6%) stage III. There was one operative death (1.8%). Complications occurred in 31 patients (57%). Median hospitalization was 13 days (range, 11 to 44 days). Follow-up was complete in all patients and ranged from 6 months to 9 years (median, 63 months). Overall 5-year survival was 86% and did not differ significantly from a population matched for age and gender. Five-year survival for patients with only high-grade dysplasia was 96% and 68% for patients with cancer (p = 0.017). Quality of life was measured by the Medical Outcomes Study 36-Item Short-Form Health Survey. For patients with only high-grade dysplasia, the role-physical and role-emotional scores were better than for the control population (p < 0.03). For patients with cancer, the health perception score was worse than for the control population (p < 0.03). Scores measuring physical-function, social function, mental health, bodily pain, and energy/fatigue were similar.

Conclusions. Although perioperative morbidity is significant, surgical resection of high-grade dysplasia in Barrett’s esophagus provides excellent long-term survival with acceptable function and quality of life.

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