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Ann Thorac Surg 2002;73:1495-1499
© 2002 The Society of Thoracic Surgeons

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Original article: cardiovascular

Myocardial preservation using celsior solution in cardiac transplantation: early results and 5-year follow-up of a multicenter prospective study of 70 cardiac transplantations

^a Cardiovascular Surgery Unit and Department of Anesthesiology, The G and R Laënnec University Hospital, Nantes, France

Accepted for publication January 11, 2002.

* Address reprint requests to Dr Remadi, Cardiovascular Surgery Unit, South Hospital, 80054 Amiens Cedex 1, Nantes, France
e-mail: remadijean-paul{at}chu-amiens.fr

Background. Several storage methods using a wide variety of extracellular or intracellular solutions applied either as continuous perfusion, intermittent perfusion, or simple immersion of the heart have been commonly used. We have performed a prospective randomized multicenter study of 70 cardiac transplantation recipients to evaluate the Celsior solution for cardiac preservation.

Methods. Seventy consecutive patients were included in this trial and received a cardiac graft arrested and preserved with Celsior. The first follow-up period was 1 month. The mean age of the recipients was 49 years (range, 28 to 66 years), and 81.7% were male. The main disease was nonobstructive cardiomyopathy (64.3%). The age range of donors was between 14 and 56 years with a mean of 33 years. The majority of grafts (73%) were stored in 1 L of Celsior. A midterm follow-up at 5 years was performed and was 100% complete.

Results. The operative mortality (<30-day) rate was 6 of 70 (8.6%). Sixty-three patients (90%) had at least satisfactory hemodynamic measurements on day 2. The first postoperative echocardiograms showed good myocardial performance for 90% of the grafts. Actuarial survival rate at 5 years was 75% ± 5.1%.

Conclusions. The use of Celsior in cardiac transplantation was safe and very effective. This solution proved very valuable in at-risk patients.Keywords. cardiac transplantation, Celsior, heart preservation

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