ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Wolfgang Ruschewski
Roland Hetzer
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buchhorn, R.
Right arrow Articles by Regitz-Zagrosek, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buchhorn, R.
Right arrow Articles by Regitz-Zagrosek, V.
Related Collections
Right arrow Cardiac - physiology

Ann Thorac Surg 2002;73:610-613
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

ß-Receptor downregulation in congenital heart disease: a risk factor for complications after surgical repair?

Reiner Buchhorn, MD*a, Martin Hulpke-Wette, MDa, Wolfgang Ruschewski, MDb, Reinhard Pregla, MDc, Jens Fielitz, MDc, Roland Hetzer, MD, PhDc, Vera Regitz-Zagrosek, MD, PhDc

a Department of Pediatric Cardiology, Georg-August-University Göttingen, Göttingen, Germany
b Department of Cardiothoracic Surgery, Georg-August-University Göttingen, Göttingen, Germany
c Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany

Accepted for publication October 18, 2001.

* Address reprint requests to Dr Buchhorn, Department of Pediatric Cardiology, Georg-August University of Gottingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany
e-mail: rbuchho{at}gwdg.de

Background. Neurohormonal activation in children with heart failure due to congenital heart disease leads to downregulation of myocardial ß-receptors that may influence the postoperative course after cardiothoracic surgery.

Methods. Myocardial biopsies of 26 children (aged 14 ± 4 months) were obtained from the right atrium during cardiac surgery. Patients were allocated to either of two groups based on the duration of their intensive care unit stay: group 1 comprised those who stayed less than 7 days (n = 17), whereas group 2 comprised those who stayed more than 7 days, plus 3 infants who died during the early postoperative course (n = 9). For ß1- and ß2-mRNA quantitation, real-time polymerase chain reaction with fluorescence-labeled products was used.

Results. Values for myocardial ß-receptor gene expression were twice as high in group 1 children compared with group 2 (ß1-receptor 0.12 ± 0.07 versus 0.06 ± 0.03, p = 0.0016; ß2-receptor 0.12 ± 0.07 versus 0.06 ± 0.03, p = 0.0071). ß-Receptor gene expression in 16 children who received standard treatment for heart failure averaged lower than in the 10 children who received additional propranolol.

Conclusions. ß-Receptor downregulation due to congestive heart failure has an impact on the postoperative course in children with congenital disease and depends on heart failure therapy.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2002 by The Society of Thoracic Surgeons.