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Ann Thorac Surg 2002;73:556-562
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

Non-blood contacting biventricular support for severe heart failure

Mark P. Anstadt, MD*a, Sebastian A. Schulte-Eistrup, MDa, Tadashi Motomura, MDa, Ernesto R. Soltero, MDa, Tamaki Takano, MDa, Issam A. Mikati, MDa, Kenji Nonaka, MDa, Fernando Joglar, MDa, Yukihiko Nosé, MD, PhDa

a The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA

* Address reprint requests to Dr Anstadt, Cardiothoracic Surgery, BA 4300, 112 15th St, Medical College of Georgia, Augusta, GA 30912-4040, USA
e-mail: manstadt{at}mail.mcg.edu

Presented at the Forty-seventh Annual Meeting of the Southern Thoracic Surgical Association, Marco Island, FL, Nov 9–11, 2000.

Background. Direct mechanical ventricular actuation (DMVA) is a non-blood contacting method of biventricular support. DMVA employs a vacuum attached, pneumatically regulated, flexible membrane to transfer both systolic and diastolic forces to the ventricular myocardium. The purpose of this study was to determine if DMVA effectively restores pump performance when applied to the severely failing heart.

Methods. Bovines (n = 10) underwent thoracotomy and were instrumented for continuous hemodynamic monitoring. Cardiac failure was induced by ß1-blockade to achieve a cardiac index of < 1.5 l/min/m2 for 1 hour. Heart rate was maintained at 100 bpm by atrioventricular sequential pacing. Synchronous DMVA support was then applied for 3 hours.

Results. Eight animals achieved significant reductions in cardiac index and mean arterial pressures (35%* and 43%* control, respectively; *p < 0.05). DMVA restored cardiac index to baseline and significantly increased arterial pressures (p < 0.05; DMVA versus cardiac failure). Pulmonary flow and mean pulmonary artery pressures were similar to baseline during DMVA (p = NS). Pathologic exam did not demonstrate evidence of significant device trauma.

Conclusions. DMVA support can effectively restore pump performance of the acutely failing heart. Synchronization may be inherent to the stimulus of cardiac compression. These data further substantiate DMVA’s potential as an adjunct to the field of circulatory support.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
M. P. Anstadt, S. Budharaju, R. J. Darner, B. A. Schmitt, L. J. Prochaska, A. J. Pothoulakis, and P. M. Portner
Ventricular actuation improves systolic and diastolic myocardial function in the small failing heart.
Ann. Thorac. Surg., December 1, 2009; 88(6): 1982 - 1988.
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