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Ann Thorac Surg 2001;72:1868-1876
© 2001 The Society of Thoracic Surgeons

Original article: general thoracic

Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer

Wu-Wei Lai, MDa, Fen-Fen Chen, MD*b, Ming-Ho Wu, MDa, Nan-Haw Chow, MDb, Wu-Chou Su, MDc, Mi-Chia Ma, PhDd, Pei-Fang Su, MSd, Helen Chen, MDe, Mu-Yen Lin, MDa, Yau-Lin Tseng, MDa

a Department of Surgery, Division of Thoracic Surgery, National Cheng Kung University, Tainan, Taiwan
b Department of Pathology, National Cheng Kung University, Tainan, Taiwan
c Department of Internal Medicine, Division of Hematology/Oncology, National Cheng Kung University, Tainan, Taiwan
d Department of College of Management Science, National Cheng Kung University, Tainan, Taiwan
e Department of Radio-Oncology, College of Medicine, and Department of Statistics, National Cheng Kung University, Tainan, Taiwan

Accepted for publication August 2, 2001.

* Address reprint requests to Dr Fen-Fen Chen, Department of Pathology, College of Medicine National Cheng Kung University, 138 Sheng Li Rd, Tainan, Taiwan 704
e-mail: fen221{at}mail.ncku.edu.tw

Background. To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence.

Methods. We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer.

Results. Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Coexpression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence.

Conclusions. The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good.




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