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Ann Thorac Surg 2001;72:1774-1782
© 2001 The Society of Thoracic Surgeons

Review

Retrograde cerebral perfusion as a method of neuroprotection during thoracic aortic surgery

David L. Reich, MD*a,b, Suzan Uysal, PhDa,b, M. Arisan Ergin, MDa,b, Randall B. Griepp, MDa,b

a Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York, USA
b Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, New York, USA

* Address reprint requests to Dr Reich, Department of Anesthesiology, Box 1010, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
e-mail: david.reich{at}mssm.edu

Retrograde cerebral perfusion is commonly used as an adjunct to hypothermic circulatory arrest to enhance cerebral protection during thoracic aortic surgery. This review summarizes a large number of studies that demonstrate a spectrum of beneficial, neutral, and detrimental effects of retrograde cerebral perfusion in humans and experimental animal models. It remains unclear whether retrograde cerebral perfusion provides effective cerebral perfusion, metabolic support, washout of embolic material, and improved neurological and neuropsychological outcome.




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