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Ann Thorac Surg 2001;72:1321-1326
© 2001 The Society of Thoracic Surgeons

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Original article: cardiovascular

Influence of steroids on microvascular perfusion injury of the bowel induced by extracorporeal circulation

^a Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
^b Experimental Surgery, University of Heidelberg, Heidelberg, Germany

Accepted for publication May 29, 2001.

Address reprint requests to Dr Sack, Department of Cardiac Surgery, University of Heidelberg, INF II0, 69I20 Heidelberg, Germany
e-mail: falk-udo.sack{at}urz.uni-heidelberg.de

Background. Extracorporeal circulation is associated with gastrointestinal complications. By means of intravital microscopic methods, we investigated whether preoperative treatment with steroids can attenuate the impairment of the bowel microcirculation.

Methods. In 20 pigs, a partial left heart bypass (pLHB) was established. A loop of the terminal ileum was exteriorized for intravital-microscopic observation. Seven sham-operated animals served as controls. In 13 animals, pLHB was established for 2 hours with a flow rate of 2,000 mL per minute; 7 of the animals received 20 mg/kg body weight prednisolone preoperatively. The microcirculatory network was analyzed before, during pLHB, and 2 hours after bypass.

Results. Despite unchanged macro-hemodynamics, pLHB resulted in a significant microvascular perfusion injury of the small bowel. Arteriolar vasoconstriction and a reduction of perfused capillaries per unit area (functional capillary density) to 30% of prebypass values could be found. Blood cell velocities were reduced in submucuous collecting venules. In the steroid-treated animals, the functional capillary density remained normal. In addition, arteriolar vasoconstriction could be prevented.

Conclusions. Treatment with prednisolone largely prevents the microcirculatory alterations in the small bowel induced by extracorporeal circulation.

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