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Right arrow Trachea and bronchi

Ann Thorac Surg 2001;72:1190-1194
© 2001 The Society of Thoracic Surgeons

Original article: general thoracic

Tracheal allotransplantation in beagle dogs without immunosuppressants

Yu Liu, MDa, Tatsuo Nakamura, MDa, Yasuhiko Shimizu, MDa, Hiroki Ueda, MDa, Makoto Yoshitani, MDa, Toshinari Toba, MDa, Seijun Fukuda, MDa

a Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Accepted for publication June 23, 2001.

Address reprint requests to Dr Liu, Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
e-mail: lyu{at}frontier.kyoto-u.ac.jp

Background. The antigenicity of tracheal grafts is still unclear. We investigated the possibility of performing tracheal allotransplantation without immunosuppressants.

Methods. Intrathoracic five-ring tracheal replacements were performed in beagle dogs without immunosuppressants (n = 18). The dogs were divided into 9 pairs, and grafts were exchanged within the pairs. In group 1 (n = 6), the paired dogs were blood relatives, whereas in group 2 (n = 12), the paired dogs were not related. Full-thickness skin transplantation was also performed in both groups.

Results. In group 1, 5 animals survived uneventfully for more than 3 months. No stenosis was observed in any of the dogs. In group 2, the grafts were incorporated by the host trachea in 2 dogs. Four animals died of airway obstruction within 3 months. Moderate or slight airway stenosis was observed in 6 dogs. Rejection was confirmed by histologic examination. In both groups, all of the skin allografts were destroyed within 2 weeks.

Conclusions. After tracheal allotransplantation, long-term survival was achieved, especially in recipient dogs that were blood relatives of donors. We conclude that it is possible to perform tracheal allotransplantation using histocompatible matched grafts without immunosuppressants.




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J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1593 - 1601.
[Abstract] [Full Text] [PDF]


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