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Robert W. Emery
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Ann Thorac Surg 2001;72:S1004-S1008
© 2001 The Society of Thoracic Surgeons

Supplement: Cardiothoracic techniques and technologies

Ventriculocoronary artery bypass results using a mesh-tipped device in a porcine model

Robert W. Emery, MDa, Frazier Eales, MDa, Clifford H. Van Meter, Jr, MDa, Mark B. Knudson, PhDb, Eric E. Solien, BSb, Katherine S. Tweden, PhDb

a Cardiac Surgical Associates, Minneapolis, Minnesota, USA
b HeartStent Corporation, Minneapolis, Minnesota, USA

Address reprint requests to Dr Emery, Cardiac Surgical Associates, 920 East 28th St, Ste 420, Minneapolis, MN 55407
e-mail: dremery{at}csa-heart.com

Presented at the Seventh Annual Cardiothoracic Techniques and Technologies Meeting 2001, New Orleans, LA, Jan 24–27, 2001.

Background. In this report we describe the in vivo evaluation of a device and ventriculocoronary artery bypass procedure that creates a permanent transmyocardial channel between the left ventricle and a coronary artery.

Methods. The transmyocardial device, an L-shaped titanium tube with a meshed distal tip and an exterior polyester cuff, was implanted from the base of the left ventricle to the proximal left anterior descending coronary artery in 11 healthy juvenile domestic pigs using a beating-heart approach. Flow rates were measured at implant. Patency was assessed at explant for surviving animals at 2 (n = 3) and 4 weeks (n = 4).

Results. Flow through the transmyocardial device after implantation was 74% of base line. Forward flow occurred during systole. Luminal patency was 100% at 2 weeks and 75% at 4 weeks. Histologic analysis showed little to no intimal proliferation at the coronary interface.

Conclusions. This short-duration study shows promise for perfusing ischemic myocardium with systolic flow. The transmyocardial titanium conduit and treated coronary artery patency was good at 2 and 4 weeks and warrants further studies.




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