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Ann Thorac Surg 2001;72:939-942
© 2001 The Society of Thoracic Surgeons

Case report

Aggressive multimodal treatment of pleuropulmonary blastoma

Susan K. Parsons, MD, MRPa,b,g, Steven J. Fishman, MDc,g, Lidewij E. Hoorntje, MDa, Diego Jaramillo, MDd,g, Karen C. Marcus, MDe,g, Antonio R. Perez-Atayde, MDf,g, Harry P. Kozakewich, MDf,g, Holcombe E. Grier, MDa,b,g, Robert C. Shamberger, MDc,g

a Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
b Division of Hematology/Oncology, Children’s Hospital, Boston, Massachusetts, USA
c Department of Surgery, Children’s Hospital, Boston, Massachusetts, USA
d Department of Radiology, Children’s Hospital, Boston, Massachusetts, USA
e Department of Radiation Oncology, Children’s Hospital, Boston, Massachusetts, USA
f Department of Pathology, Children’s Hospital, Boston, Massachusetts, USA
g Harvard Medical School, Boston, Massachusetts, USA

Accepted for publication August 28, 2000.

Address reprint requests to Dr Parsons, Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115
e-mail: sparsons{at}partners.org

Pleuropulmonary blastoma is a rare intrathoracic neoplasm almost solely confined to childhood. Survival is poor. The authors report 2 children with extensive intrathoracic disease who are long term survivors after multimodal therapy. Both children received multiagent neoadjuvant chemotherapy, followed by surgical resection to remove all gross tumor. Postoperative chemotherapy was given to both children; radiotherapy was also given in the second case because of a question of positive tumor margins. Experience supports the use of multimodal therapy, including an aggressive surgical approach in the potentially curative treatment of this tumor.




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