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Ann Thorac Surg 2001;72:753-757
© 2001 The Society of Thoracic Surgeons

Original article: cardiovascular

Age and valve size effect on the long-term durability of the Carpentier-Edwards aortic pericardial bioprosthesis

Michael K. Banbury, MDa, Delos M. Cosgrove, III, MDa, Jennifer A. White, MSa, Eugene H. Blackstone, MDa, Robert W. M. Frater, MDb, J. Edward Okies, MDc

a Departments of Thoracic and Cardiovascular Surgery and Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
b Department of Thoracic and Cardiovascular Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA
c Department of Thoracic and Cardiovascular Surgery, Good Samaritan Hospital, Portland, Oregon, USA

Accepted for publication June 11, 2001.

Address reprint requests to Dr Banbury, The Cleveland Clinic Foundation, 9500 Euclid Ave, Desk F25, Cleveland, OH 44195
e-mail: banburm{at}ccf.org

Background. Bioprosthesis durability decreases with time and younger age. However, the time-scale and determinants of durability of the aortic Carpentier-Edwards stented bovine pericardial prosthesis are incompletely characterized.

Methods. Between September 1981 and January 1984, 267 patients underwent implantation of the pericardial aortic prosthesis at four centers. Mean age at implant was 65 ± 12 years (range 21 to 86 years). Follow-up averaged 12 ± 4.5 years. The primary end point was explant for structural valve dysfunction (SVD), which was analyzed multivariably in the context of death as a competing risk.

Results. Freedom from explant due to SVD was 99%, 94%, and 77% at 5, 10, and 15 years. Risk of SVD increased exponentially with time and younger age (p = 0.0001) at implantation; an increased risk of small valve size was not reliably demonstrated (p = 0.1). Considering the competing risk of death, patients aged 65 years or older had a less than 10% chance of explant for SVD by 15 years.

Conclusions. Durability of this stented pericardial aortic bioprosthesis is excellent and justifies its use in patients aged 65 or older.




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