| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2001;72:527-533
© 2001 The Society of Thoracic Surgeons
a Hygeia Associates, Grass Valley, California, USA
b Department of Medicine, Sunnybrook and Women’s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Accepted for publication April 13, 2001.
Address reprint requests to Dr Wilkes, Hygeia Associates, 17988 Brewer Rd, Grass Valley, CA 95949
e-mail: mwilkes{at}hygeiaassociates.com
Background. This meta-analysis tested the hypothesis that cumulative blood loss during the first 24 hours after cardiopulmonary bypass is lower in patients exposed to albumin than hydroxyethyl starch (HES).
Methods. Randomized controlled trials comparing albumin and HES in cardiopulmonary bypass patients were identified by bibliographic database searches and other methods.
Results. Sixteen trials involving 653 randomized patients were included. In 88% of randomized comparisons, postoperative bleeding was lower in the albumin group, and the standardized mean difference in bleeding favoring albumin across all trials (-0.24; 95% confidence interval, -0.40 to -0.08) was statistically significant. Bleeding differences between albumin and either high or medium molecular weight HES were similar. In trials of adults, the pooled mean blood loss in the albumin group was 693 ± 350 mL compared with 789 ± 487 mL in the HES group. The estimated proportion of adult albumin group patients with blood loss of more than 1,000 mL was 19% compared with 33% of adult HES group patients.
Conclusions. Postoperative blood loss is significantly lower in cardiopulmonary bypass patients exposed to albumin than HES.
Related Article
Ann. Thorac. Surg. 2001 72: 534.
This article has been cited by other articles:
|
|
 |
|
  J. Boldt, S. Suttner, C. Brosch, A. Lehmann, and A. Mengistu Influence on coagulation of a potato-derived hydroxethylstarch (HES 130/0.42) and a maize-derived hydroxethylstarch (HES 130/0.4) in patients undergoing cardiac surgery Br. J. Anaesth., February 1, 2009; 102(2): 191 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hartog, F. Brunkhorst, and K. Reinhart Hydroxyethyl Starch 130/0.4 and Surgical Blood Loss Anesth. Analg., February 1, 2009; 108(2): 672 - 672. [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kozek-Langenecker, C. Jungheinrich, W. Sauermann, and P. van der Linden Hydroxyethyl Starch 130/0.4 and Surgical Blood Loss Anesth. Analg., February 1, 2009; 108(2): 672 - 673. [Full Text] [PDF]
|
|
|
|
|
|
A. A. Schramko, R. T. Suojaranta-Ylinen, A. H. Kuitunen, S. I. Kukkonen, and T. T. Niemi Rapidly Degradable Hydroxyethyl Starch Solutions Impair Blood Coagulation After Cardiac Surgery: A Prospective Randomized Trial Anesth. Analg., January 1, 2009; 108(1): 30 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kozek-Langenecker, C. Jungheinrich, W. Sauermann, and P. Van der Linden The Effects of Hydroxyethyl Starch 130/0.4 (6%) on Blood Loss and Use of Blood Products in Major Surgery: A Pooled Analysis of Randomized Clinical Trials Anesth. Analg., August 1, 2008; 107(2): 382 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Brunkhorst, C. Engel, F. Bloos, A. Meier-Hellmann, M. Ragaller, N. Weiler, O. Moerer, M. Gruendling, M. Oppert, S. Grond, et al. Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis N. Engl. J. Med., January 10, 2008; 358(2): 125 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Boldt, M. Wolf, and A. Mengistu A New Plasma-Adapted Hydroxyethylstarch Preparation: In Vitro Coagulation Studies Using Thrombelastography and Whole Blood Aggregometry Anesth. Analg., February 1, 2007; 104(2): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Boldt, T. Scholhorn, J. Mayer, S. Piper, and S. Suttner The value of an albumin-based intravascular volume replacement strategy in elderly patients undergoing major abdominal surgery. Anesth. Analg., July 1, 2006; 103(1): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. Niemi, R. T. Suojaranta-Ylinen, S. I. Kukkonen, and A. H. Kuitunen Gelatin and hydroxyethyl starch, but not albumin, impair hemostasis after cardiac surgery. Anesth. Analg., April 1, 2006; 102(4): 998 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Gu and P. W. Boonstra Selection of priming solutions for cardiopulmonary bypass in adults MMCTS, January 9, 2006; 2006(0109): 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dial, E. Delabays, M. Albert, A. Gonzalez, J. Camarda, A. Law, and D. Menzies Hemodilution and surgical hemostasis contribute significantly to transfusion requirements in patients undergoing coronary artery bypass J. Thorac. Cardiovasc. Surg., September 1, 2005; 130(3): 654 - 654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Farstad, V. L. Kvalheim, and P. Husby Cold-induced fluid extravasation during cardiopulmonary bypass in piglets can be counteracted by use of iso-oncotic prime J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 287 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Evidence-based Colloid Use in the Critically Ill: American Thoracic Society Consensus Statement Am. J. Respir. Crit. Care Med., December 1, 2004; 170(11): 1247 - 1259. [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Wilkes, R. J. Navickis, J. Avorn, and W. Winkelmayer Hydroxyethyl Starch-Induced Postoperative Bleeding in Cardiac Surgery Patients: More Trials Needed? Chest, July 1, 2004; 126(1): 311 - 312. [Full Text] [PDF]
|
|
|
|
|
|
I. Celik, J. Boldt, and H.-J. Priebe Renal dysfunction after hydroxyethyl starch. Anesth. Analg., July 1, 2004; 99(1): 309 - 310. [Full Text] [PDF]
|
|
|
|
|
|
A. Shander, T. Rijhwani, D. Moskowitz, and R. Spence Blood and Starch in Cardiac Surgery Chest, June 1, 2004; 125(6): 2369 - 2370. [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Barron, M. M. Wilkes, and R. J. Navickis A Systematic Review of the Comparative Safety of Colloids Arch Surg, May 1, 2004; 139(5): 552 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Moskowitz, J. J. Klein, A. Shander, K. M. Cousineau, R. S. Goldweit, C. Bodian, S. I. Perelman, H. Kang, D. A. Fink, H. C. Rothman, et al. Predictors of transfusion requirements for cardiac surgical procedures at a blood conservation center Ann. Thorac. Surg., February 1, 2004; 77(2): 626 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Boldt New Light on Intravascular Volume Replacement Regimens: What Did We Learn from the Past Three Years? Anesth. Analg., December 1, 2003; 97(6): 1595 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Avorn, M. Patel, R. Levin, and W. C. Winkelmayer Hetastarch and Bleeding Complications After Coronary Artery Surgery Chest, October 1, 2003; 124(4): 1437 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sedrakyan, K. Gondek, D. Paltiel, and J. A. Elefteriades Volume Expansion With Albumin Decreases Mortality After Coronary Artery Bypass Graft Surgery Chest, June 1, 2003; 123(6): 1853 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Wilkes Reply Ann. Thorac. Surg., May 1, 2003; 75(5): 1683 - 1683. [Full Text] [PDF]
|
|
|
|
|
|
M. Durand and O. Chavanon Does hydroxyethyl starch increase blood loss in cardiac operations Ann. Thorac. Surg., May 1, 2003; 75(5): 1682 - 1683. [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Hessel II and L. H. Edmunds Jr. Extracorporeal Circulation: Perfusion Systems Card. Surg. Adult, January 1, 2003; 2(2003): 317 - 338. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
